SCD2 Activators
The category of SCD2 activators comprises a diverse group of compounds designed to modulate the activity of stearoyl-CoA desaturase 2 (SCD2), a pivotal enzyme involved in lipid metabolism. SCD2 plays a crucial role in catalyzing the desaturation of saturated fatty acids, a key step in the biosynthesis of monounsaturated fatty acids. Activators within this class may operate by directly influencing the enzymatic function of SCD2 or indirectly by modulating signaling pathways and cellular processes associated with lipid metabolism.
Direct SCD2 activators may impact the enzymatic activity of the desaturase directly, either by providing essential substrates for its activity or by directly influencing the catalytic site. Alternatively, indirect activators exert their influence by modulating signaling pathways associated with lipid metabolism. These pathways may regulate gene expression, substrate availability, or cellular energy status, ultimately leading to enhanced SCD2 activity. The dynamic interplay between SCD2 and its activators provides a nuanced understanding of the regulatory mechanisms governing lipid metabolism and the cellular processes influenced by SCD2 activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516, a PPARδ agonist, activates peroxisome proliferator-activated receptor δ (PPARδ), a transcription factor involved in lipid metabolism. Activation of PPARδ can lead to upregulation of genes involved in fatty acid oxidation and may indirectly enhance SCD2 activity by influencing lipid substrates. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMP-activated protein kinase (AMPK) activator, stimulates AMPK, a key energy sensor. Activation of AMPK can influence lipid metabolism and may indirectly activate SCD2 by modulating cellular energy status and substrate availability for lipid biosynthesis. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid, a polyunsaturated fatty acid, is a direct substrate for SCD2. Its availability can directly influence the desaturation activity of SCD2, promoting the conversion of saturated to monounsaturated fatty acids. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K-Akt pathway, which is involved in lipid metabolism. Insulin-induced pathway activation can indirectly enhance SCD2 activity by influencing the availability of lipid substrates for desaturation. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid, a monounsaturated fatty acid, serves as a direct substrate for SCD2. Its availability can directly influence the enzymatic activity of SCD2, promoting the conversion of saturated fatty acids to monounsaturated fatty acids. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid, a polyunsaturated fatty acid, serves as a direct substrate for SCD2. Its availability can directly impact the enzymatic activity of SCD2, facilitating the conversion of saturated fatty acids to monounsaturated fatty acids. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin, also known as nicotinic acid, can activate G protein-coupled receptor 109A (GPR109A). Activation of GPR109A may influence lipid metabolism and can potentially enhance SCD2 activity by modulating downstream signaling pathways that regulate fatty acid desaturation. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA, a polyunsaturated fatty acid, serves as a direct substrate for SCD2. Its availability can directly influence the enzymatic activity of SCD2, promoting the conversion of saturated fatty acids to monounsaturated fatty acids. | ||||||