SCD2 Inhibitors
The category of SCD2 inhibitors encompasses a diverse array of chemical compounds designed to influence the activity of stearoyl-CoA desaturase 2 (SCD2), a pivotal enzyme integral to lipid metabolism. SCD2 serves a critical function in catalyzing the desaturation of saturated fatty acids, a key step in the biosynthesis of monounsaturated fatty acids. This enzymatic process contributes substantially to the cellular lipid profile, impacting membrane composition and influencing various aspects of cellular physiology.
Direct inhibitors within this class operate by specifically targeting the enzymatic function of SCD2. These compounds interact with the catalytic site of the enzyme, disrupting its ability to facilitate the conversion of saturated fatty acids to monounsaturated fatty acids. By directly impeding the enzymatic activity of SCD2, these inhibitors modulate the composition of cellular lipid pools, influencing downstream lipid-related pathways and cellular processes. In contrast, indirect inhibitors of SCD2 exert their influence by targeting key components of pathways associated with lipid metabolism. These compounds perturb cellular processes or pathways that converge on SCD2, altering the availability of substrates crucial for its enzymatic activity. This indirect modulation impacts the flux of fatty acid desaturation catalyzed by SCD2, thus providing an alternative avenue for influencing cellular lipid profiles. Overall, the diverse repertoire of SCD2 inhibitors serves as valuable tools for scientists probing the intricate regulatory mechanisms governing lipid metabolism. The nuanced understanding from the modulation of SCD2 activity by these inhibitors contributes to unraveling the complex interplay of molecular events governing lipid homeostasis within cells.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CAY 10566 | 944808-88-2 | sc-205109 sc-205109A sc-205109B | 1 mg 5 mg 25 mg | $117.00 $512.00 $1527.00 | 4 | |
CAY10566 is a compound that selectively inhibits SCD2 activity. It has been utilized in research studies to explore the role of SCD2 in lipid metabolism and its implications in various diseases. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin (synthetic) acts as an indirect inhibitor by targeting fatty acid synthase (FASN), a crucial enzyme in lipid biosynthesis. The inhibition of FASN disrupts the synthesis of fatty acids, indirectly influencing the substrates available for SCD2 and modulating its enzymatic activity. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan is an indirect inhibitor that disrupts fatty acid metabolism by inhibiting enoyl-acyl carrier protein reductase (ENR). The perturbation in lipid biosynthesis can impact the availability of substrates for SCD2, leading to modulation of its enzymatic activity. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
NDGA acts indirectly by inhibiting 5-lipoxygenase, a key enzyme in arachidonic acid metabolism. This disruption in lipid metabolism can influence the substrates available for SCD2, leading to modulation of its enzymatic activity. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Gallotannin serves as an indirect inhibitor by targeting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), a critical enzyme in the mevalonate pathway. This inhibition disrupts cholesterol biosynthesis, indirectly impacting the substrates available for SCD2 and modulating its enzymatic activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate acts as an indirect inhibitor by modulating AMP-activated protein kinase (AMPK), a key regulator of cellular energy status. This indirect modulation can influence lipid metabolism, subsequently affecting the substrates available for SCD2 and modulating its enzymatic activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose acts as an indirect inhibitor by disrupting glycolysis. The inhibition of glycolysis influences the availability of metabolites for lipid biosynthesis, indirectly affecting the substrates available for SCD2 and modulating its enzymatic activity. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
(+)-Etomoxir sodium salt acts as an indirect inhibitor by inhibiting carnitine palmitoyltransferase 1 (CPT-1), a key enzyme in fatty acid oxidation. This disruption in fatty acid metabolism can impact the substrates available for SCD2, leading to modulation of its enzymatic activity. | ||||||