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(−)-Epigallocatechin Gallate (CAS 989-51-5)

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Alternate Names:
(−)-Epigallocatechin Gallate is also known as EGCG.
Application:
(−)-Epigallocatechin Gallate is a strong polyphenol catechin antioxidant and inhibitor of Bcl-2 and NOS2.
CAS Number:
989-51-5
Purity:
≥97%
Molecular Weight:
458.37
Molecular Formula:
C22H18O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDL) is correlated to cardiovascular diseases, and (−)-Epigallocatechin Gallate is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells, and (−)-Epigallocatechin Gallate (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. (−)-Epigallocatechin Gallate also inhibits NOS2 (iNOS).


(−)-Epigallocatechin Gallate (CAS 989-51-5) References

  1. Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate.  |  Kang, WS., et al. 1999. Thromb Res. 96: 229-37. PMID: 10588466
  2. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate.  |  Kao, YH., et al. 2000. Endocrinology. 141: 980-7. PMID: 10698173
  3. Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media.  |  Long, LH., et al. 2000. Biochem Biophys Res Commun. 273: 50-3. PMID: 10873562
  4. Fenton reaction is primarily involved in a mechanism of (-)-epigallocatechin-3-gallate to induce osteoclastic cell death.  |  Nakagawa, H., et al. 2002. Biochem Biophys Res Commun. 292: 94-101. PMID: 11890677
  5. Protective activity of green tea against free radical- and glucose-mediated protein damage.  |  Nakagawa, T., et al. 2002. J Agric Food Chem. 50: 2418-22. PMID: 11929306
  6. Direct scavenging of nitric oxide and superoxide by green tea.  |  Nakagawa, T. and Yokozawa, T. 2002. Food Chem Toxicol. 40: 1745-50. PMID: 12419687
  7. (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA.  |  Furukawa, A., et al. 2003. Biochem Pharmacol. 66: 1769-78. PMID: 14563487
  8. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.  |  Leone, M., et al. 2003. Cancer Res. 63: 8118-21. PMID: 14678963
  9. Oxidative modification of LDL: its pathological role in atherosclerosis.  |  Itabe, H. 2009. Clin Rev Allergy Immunol. 37: 4-11. PMID: 18987785
  10. Metabolism of (-)-epigallocatechin gallate by rat intestinal flora.  |  Takagaki, A. and Nanjo, F. 2010. J Agric Food Chem. 58: 1313-21. PMID: 20043675
  11. Effects of various natural antioxidants on the Cu(2+)-mediated oxidative modification of low density lipoprotein.  |  Miura, S., et al. 1995. Biol Pharm Bull. 18: 1-4. PMID: 7735221
  12. Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage.  |  Cherbonnel-Lasserre, C. and Dosanjh, MK. 1997. Biochimie. 79: 613-7. PMID: 9466700
  13. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts.  |  Chen, ZP., et al. 1998. Cancer Lett. 129: 173-9. PMID: 9719459
  14. Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK.  |  Lu, LH., et al. 1998. Br J Pharmacol. 124: 1227-37. PMID: 9720795
  15. Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate.  |  Paschka, AG., et al. 1998. Cancer Lett. 130: 1-7. PMID: 9751250

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-Epigallocatechin Gallate, 10 mg

sc-200802
10 mg
$43.00

(−)-Epigallocatechin Gallate, 50 mg

sc-200802A
50 mg
$73.00

(−)-Epigallocatechin Gallate, 100 mg

sc-200802B
100 mg
$126.00

(−)-Epigallocatechin Gallate, 500 mg

sc-200802C
500 mg
$243.00

(−)-Epigallocatechin Gallate, 1 g

sc-200802D
1 g
$530.00

(−)-Epigallocatechin Gallate, 10 g

sc-200802E
10 g
$1259.00