SBZF3 Inhibitors
Chemical inhibitors of SBZF3 offer a range of mechanisms by which the protein's function can be modulated. Staurosporine is a broad-spectrum protein kinase inhibitor that can suppress the activity of kinases necessary for the activation or modification of SBZF3, thereby inhibiting its function. Similarly, LY294002 targets the PI3K/Akt pathway, which, if involved in regulating SBZF3, can lead to its decreased activation. PD98059 and U0126 both act as selective inhibitors of MEK, a kinase that operates upstream of ERK in the MAPK pathway. The inhibition of MEK by these compounds would result in reduced ERK activation, which in turn can lead to a decrease in SBZF3 activity if it is regulated through this pathway. SP600125 and SB203580 specifically inhibit JNK and p38 MAP kinase, respectively, both of which are components of the MAPK signaling pathways. The inhibition of these kinases can lead to a decrease in SBZF3 activity if the protein is regulated by these pathways.
Additional compounds that target various kinases also play a role in the regulation of SBZF3 activity. PP2, as an inhibitor of Src family kinases, can lead to the inhibition of SBZF3 if it is regulated by signals from this family of kinases. Y-27632, which inhibits ROCK, can inhibit SBZF3 if the protein's function is modulated by ROCK signaling. Wortmannin provides another layer of regulation by inhibiting PI3K, leading to the suppression of SBZF3 activity if PI3K signaling is involved in its regulation. Rapamycin's inhibition of mTOR can also result in the inhibition of SBZF3 if mTOR signaling affects the protein's activity. Lastly, Bisindolylmaleimide I and Gö6976 target PKC, with the former being a broad-spectrum PKC inhibitor and the latter more selective for classical PKC isoforms. If SBZF3 activity is regulated by PKC-dependent signaling, the use of these inhibitors can prevent the activation or modulation of SBZF3, thus inhibiting its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. SBZF3's function can be inhibited by staurosporine through the suppression of kinase activity that is essential for the post-translational modifications or activation of SBZF3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K/Akt pathway. Since SBZF3 may be regulated by Akt-mediated signals, inhibition of this pathway by LY294002 can result in the decreased activation and thereby inhibition of SBZF3's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which works upstream of ERK in the MAPK pathway. Given that SBZF3 may be regulated as part of the MAPK pathway signaling cascade, inhibition of MEK by PD98059 could lead to a decrease in ERK activation, thereby inhibiting SBZF3's function that relies on this signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is part of the MAPK signaling pathways. Inhibition of JNK by SP600125 could lead to functional inhibition of SBZF3 if SBZF3 is regulated by the JNK signaling. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
SB203580 is a specific inhibitor of p38 MAP kinase. If SBZF3's activity is modulated by p38 MAPK signaling, then inhibition of p38 MAPK by SB203580 can inhibit the functional activity of SBZF3 by preventing its activation through this pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor. If SBZF3 is regulated by Src family kinase signaling, inhibition of these kinases by PP2 could result in the functional inhibition of SBZF3. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK). ROCK signaling can influence various cellular functions, and if SBZF3's activity is modulated by ROCK, inhibition of ROCK by Y-27632 can lead to inhibition of SBZF3's function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, and by inhibiting these kinases, it can prevent the activation of downstream ERK. If SBZF3's function is dependent on ERK signaling, its inhibition through U0126 can result in functional inhibition of SBZF3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). If PI3K signaling regulates SBZF3's activity, inhibition of PI3K by Wortmannin can lead to SBZF3's functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, and mTOR signaling can affect various cellular processes. If SBZF3 is regulated as part of the mTOR signaling pathway, inhibition of mTOR by Rapamycin can result in the functional inhibition of SBZF3. | ||||||