RyR-1 Activators
RyR-1 activators belong to a specialized class of chemical compounds designed to modulate the activity of the Ryanodine Receptor type 1 (RyR-1), a critical calcium release channel predominantly found in skeletal muscle cells. RyR-1 plays an essential role in excitation-contraction coupling, a process that underlies muscle contraction. When an action potential propagates along the skeletal muscle membrane, it triggers the opening of voltage-gated calcium channels, allowing calcium ions to enter the muscle cell. Subsequently, this influx of calcium ions induces the release of calcium from intracellular stores within the sarcoplasmic reticulum (SR) via RyR-1. This released calcium then binds to contractile proteins, ultimately leading to muscle contraction. Consequently, RyR-1 activation is pivotal for the proper functioning of skeletal muscles and is tightly regulated to ensure precise control over muscle contraction and relaxation.
RyR-1 activators are designed to interact with the RyR-1 receptor, influencing its activity and modulating calcium release from the SR. These compounds serve as crucial tools for researchers studying the molecular mechanisms of muscle contraction and the regulation of intracellular calcium dynamics in skeletal muscle cells. By manipulating RyR-1 activity, scientists can gain insights into the intricate processes that govern muscle function and calcium signaling in muscle tissues, contributing to our understanding of muscular physiology and the mechanisms underlying conditions related to muscle dysfunction. RyR-1 activators play a vital role in advancing our knowledge of excitation-contraction coupling and its relevance to muscle function and performance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene is known to interact with RyR-1, potentially modulating its expression by altering calcium ion flow in muscle cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine may influence RyR-1 expression by affecting calcium signaling pathways within muscle cells. | ||||||
2-Bromo-2-chloro-1,1,1-trifluoroethane | 151-67-7 | sc-251705 sc-251705A | 125 ml 250 ml | $172.00 $300.00 | ||
2-Bromo-2-chloro-1,1,1-trifluoroethane is suggested to interact with RyR-1, potentially altering its expression through modulation of calcium channels in muscle tissues. | ||||||
Isoflurane | 26675-46-7 | sc-470926 sc-470926A | 5 g 25 g | $68.00 $215.00 | 7 | |
Isoflurane may affect RyR-1 expression by impacting calcium dynamics in skeletal muscle cells. | ||||||
Chloroform | 67-66-3 | sc-239527A sc-239527 | 1 L 4 L | $110.00 $200.00 | 1 | |
Chloroform has been shown to interact with RyR-1, potentially influencing its expression by modulating calcium handling in cells. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine may modulate RyR-1 expression by altering calcium ion flow, particularly in muscle cells. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C can affect RyR-1 expression by disrupting intracellular calcium signaling, which is vital for muscle function. | ||||||
Azumolene Sodium Salt | 105336-14-9 | sc-207313 | 10 mg | $330.00 | 2 | |
Azumolene Sodium Salt is a derivative of dantrolene and may influence RyR-1 expression similarly by modulating calcium dynamics in muscle cells. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $108.00 $189.00 $399.00 $616.00 | 1 | |
Procaine might affect RyR-1 expression by impacting calcium ion channels and their regulatory mechanisms in muscle tissues. | ||||||