Molecular structure of Isoflurane, CAS Number: 26675-46-7
Isoflurane (CAS 26675-46-7)
See product citations (7)
Alternate Names:
Isoflurane is also known as (±)-Isoflurane.
Application:
Isoflurane is a halogenated ether with anesthetic properties, useful solvent for dispersing fluorinated materials.
CAS Number:
26675-46-7
Purity:
≥97%
Molecular Weight:
184.49
Molecular Formula:
C3H2ClF5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Isoflurane is leveraged in research to study the underlying mechanisms of general anesthesia and its influence on cellular and molecular processes. Investigations often focus on its interactions with neuronal ion channels, modulation of neurotransmitter systems, and effects on synaptic plasticity. Research on isoflurane also includes examining its role in the regulation of mitochondrial function and its impact on neuroprotection under conditions that can lead to cellular stress. Additionally, the compound is used to research its effects on the inflammatory response and on the regulation of gene expression related to stress and anesthetic exposure.
Isoflurane (CAS 26675-46-7) References
- The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. | Xie, Z., et al. 2007. J Neurosci. 27: 1247-54. PMID: 17287498
- A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice. | Wang, X., et al. 2016. Genet Mol Res. 15: PMID: 27323147
- Prolonged duration of isoflurane anesthesia impairs spatial recognition memory through the activation of JNK1/2 in the hippocampus of mice. | Jiang, S., et al. 2017. Neuroreport. 28: 386-390. PMID: 28240723
- Isoflurane Increases Tolerance to Renal Ischemia Reperfusion Injury Compared to Propofol: An Experimental Study in Pigs. | Roaldsen, M., et al. 2021. J Invest Surg. 34: 359-365. PMID: 31288581
- Isoflurane increases cell membrane fluidity significantly at clinical concentrations. | Patel, J., et al. 2020. Biochim Biophys Acta Biomembr. 1862: 183140. PMID: 31790694
- Isoflurane and Carbon Dioxide Elicit Similar Behavioral Responses in Rats. | Kulkarni, S. and Hickman, D. 2020. Animals (Basel). 10: PMID: 32824345
- Isoflurane activates AMP-activated protein kinase to inhibit proliferation, and promote apoptosis and autophagy in cervical carcinoma both in vitro and in vivo. | Wei, H., et al. 2021. J Recept Signal Transduct Res. 41: 538-545. PMID: 33043765
- ISOFLURANE RESPIRATORY ANESTHETIC INDEX IN CHICKENS (GALLUS GALLUS DOMESTICUS). | Midon, M., et al. 2021. J Zoo Wildl Med. 52: 327-331. PMID: 33827194
- Isoflurane induces liver injury by modulating the expression of miR-125a-5p. | Li, X., et al. 2021. Clin Res Hepatol Gastroenterol. 45: 101732. PMID: 34139319
- Isoflurane Suppresses Proliferation, Migration, and Invasion and Facilitates Apoptosis in Colorectal Cancer Cells Through Targeting miR-216. | Cai, Z., et al. 2021. Front Med (Lausanne). 8: 658926. PMID: 34458282
- Neonatal isoflurane exposure disturbs granule cell migration in the rat dentate gyrus. | Uchida, Y., et al. 2022. Biomed Res. 43: 1-9. PMID: 35173111
- Isoflurane Promotes Cell Proliferation, Invasion, and Migration by Regulating BACH1 and miR-375 in Prostate Cancer Cells In Vitro. | Zheng, J., et al. 2022. Int J Toxicol. 41: 212-224. PMID: 35532539
- Effects of isoflurane anesthesia on addictive behaviors in rats. | Yoon, SS., et al. 2022. Psychopharmacology (Berl). 239: 3621-3632. PMID: 36109391
- Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats. | Nagy, SA., et al. 2023. Sci Rep. 13: 5598. PMID: 37019923
- Assessment of complementary white matter microstructural changes and grey matter atrophy in a preclinical model of Alzheimer's disease. | Bergamino, M., et al. 2023. Magn Reson Imaging.. PMID: 37028608
- Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis | Q Liu, X Wang, Y Hu, JN Zhao, CH Huang, T Li. June 2023,. Redox Biology. Volume 62,: 102697.
Inhibitor of:
GABAA R rho 1, GABAA Rε, GABAA Rγ2, Olfr456, Olfr851, Olfr859, Olr32, TALK-1, Troponin T-FS, and Vmn2r69.Activator of:
5′-nucleotidas, 52 kDa Ro/SSA, GABAA R α 1, GABAA R α 3, GABAA R α 4, GABAA R β 3, GABAA Rβ1, GABAA Rε, GABAA Rγ1, GABAA Rγ2, GABAA Rρ1, GABAA Rρ2, GABAA Rθ, GABAA Rp, HERG, NDUFA4, RyR-1, and TASK-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoflurane, 5 g | sc-470926 | 5 g | $69.00 | |||
Isoflurane, 25 g | sc-470926A | 25 g | $219.00 |