Rtn-1 Activators
Rtn-1 activators are a diverse array of chemical compounds that enhance the functional activity of Rtn-1, each through a distinctive modality. Forskolin, through the elevation of cAMP, indirectly augments the activity of Rtn-1 by PKA-mediated phosphorylation, which could potentiate its role in membrane remodeling. PMA, as a PKC activator, and Ionomycin, through calcium ionophore activity, both lead to post-translational modifications of Rtn-1, possibly enhancing its efficacy in inducing membrane curvature. Spermine, through its interaction with membrane phospholipids, and Arachidonic acid, by altering membrane fluidity, create anoptimal environment that may amplify Rtn-1's intrinsic membrane-shaping activities. FTY720 and Cyclic ADP-Ribose, by modulating sphingolipid and calcium signaling respectively, indirectly influence the lipid milieu and calcium-dependent processes that Rtn-1 may capitalize on to exert its effects on membrane dynamics. The subtle yet significant changes in membrane properties induced by Curcumin, NAD+, and Docosahexaenoic acid (DHA), through various kinase activity modulations, redox reactions, and fluidity alterations, respectively, might enhance Rtn-1's interaction with cellular membranes, promoting its activity.
Furthermore, Retinoic acid, by potentially affecting gene expression related to lipid metabolism, could create favorable conditions for Rtn-1's functional engagement with membranes, while Lithium chloride's impact on the inositol phosphate pathway may influence Rtn-1's stability and localization, indirectly enhancing its activity. These activators, through intricate and interconnected signaling pathways, ensure the potentiation of Rtn-1 without necessitating an increase in its expression levels or direct activation. Collectively, these compounds exert their effects by optimizing the cellular and molecular landscape in which Rtn-1 operates, thereby facilitating an enhanced functional state of this protein that is pivotal for maintaining the structural integrity of cellular membranes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts by activating adenylyl cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate Rtn-1, potentially leading to changes in its conformation and enhancing its membrane-curvature-inducing activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of Rtn-1, which may enhance its interaction with other membrane-shaping proteins and increase its membrane remodeling activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may phosphorylate Rtn-1, potentially enhancing its ability to induce membrane curvature. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can stabilize negatively charged phospholipid head groups. This stabilization can change the local lipid environment favorable for Rtn-1, enhancing its ability to induce tubular membrane structures. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid is a fatty acid that can be incorporated into cellular membranes, modifying their properties. The altered membrane fluidity and curvature may synergize with Rtn-1's function to promote its membrane-shaping activity. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 is a sphingosine-1-phosphate receptor modulator. By influencing sphingolipid signaling, it can alter the membrane lipid composition, potentially enhancing the membrane deformation effects of Rtn-1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate the activity of various kinases and signaling pathways. Through these interactions, it might promote the phosphorylation state or localization of Rtn-1 conducive to its activation. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is involved in redox reactions and can also serve as a substrate for ADP-ribosylation reactions. Such post-translational modifications of proteins can affect Rtn-1's activity by altering its interactions with other proteins or lipids. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA is an omega-3 fatty acid that can be incorporated into cell membranes, affecting their fluidity and curvature. This could enhance the activity of Rtn-1 in membrane remodeling processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate gene expression and cellular differentiation processes. It may also influence the lipid composition of membranes, potentially aiding Rtn-1 in its membrane-associated functions. | ||||||