Date published: 2025-10-25

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ROG Inhibitors

The term ROG Inhibitors refers to a class of chemical compounds designed to modulate the function of receptor-operated gates (ROGs) within biological systems. ROGs are specialized protein complexes that play a pivotal role in cellular communication and signal transduction processes. These gates consist of transmembrane proteins and ion channels regulating the flow of ions like calcium, sodium, and potassium across cell membranes. Their primary function is to control essential cellular processes, including neuronal excitation, muscle contraction, and secretion of signaling molecules.ROG inhibitors form a diverse group of chemical agents, each with a unique mechanism of action. These compounds are engineered to interfere with ROG operation, often by modulating ion channel activity or other crucial components.

ROG inhibitors act as calcium channel blockers, impeding calcium ions from entering cells, essential for signal transmission. Others may target specific receptor proteins, like NMDA receptors or GABA receptors, involved in ROG-mediated processes within the nervous system. By selectively binding or blocking these components, ROG inhibitors can finely regulate cellular responses, effectively controlling or dampening the signal transmission facilitated by these gates.The versatility of ROG inhibitors makes them invaluable tools for studying cellular physiology and signal transduction pathways. Researchers use these compounds to gain insights into the intricacies of ROG-mediated processes and their roles in various physiological contexts. By manipulating ROGs with inhibitors, scientists can dissect the underlying mechanisms of cellular communication, enabling a deeper understanding of fundamental biological processes. The primary purpose of ROG inhibitors lies in their utility as research agents for unraveling the complexities of cellular signaling networks.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$58.00
$170.00
15
(1)

Nifedipine is a calcium channel blocker that inhibits ROG by blocking L-type calcium channels, reducing calcium influx into cells, and subsequently preventing the activation of downstream signaling pathways involved in gate opening.

Amlodipine

88150-42-9sc-200195
sc-200195A
100 mg
1 g
$73.00
$163.00
2
(1)

Amlodipine, like nifedipine, is a calcium channel blocker that specifically targets L-type calcium channels, inhibiting ROG by reducing calcium entry and preventing gate activation.

Nimodipine

66085-59-4sc-201464
sc-201464A
100 mg
1 g
$60.00
$301.00
2
(1)

Nimodipine is a calcium channel blocker with a preference for cerebral blood vessels. It inhibits ROG by selectively blocking L-type calcium channels, preventing calcium influx and gate activation.

5,5-Diphenyl Hydantoin

57-41-0sc-210385
5 g
$70.00
(0)

Phenytoin inhibits ROG by stabilizing sodium channels, reducing neuronal excitability, and preventing excessive channel opening, ultimately affecting gate function.

Lamotrigine

84057-84-1sc-201079
sc-201079A
10 mg
50 mg
$118.00
$476.00
1
(1)

Lamotrigine inhibits ROG by modulating voltage-gated sodium channels. It reduces excessive sodium influx into neurons, dampening excitability and gate activation.

Gabapentin

60142-96-3sc-201481
sc-201481A
sc-201481B
20 mg
100 mg
1 g
$52.00
$92.00
$132.00
7
(1)

Gabapentin acts as a GABA analog and inhibits ROG by enhancing GABAergic inhibition. It indirectly inhibits neuronal excitation, reducing gate activation by modulating ion channel activity.

Topiramate

97240-79-4sc-204350
sc-204350A
10 mg
50 mg
$105.00
$362.00
(1)

Topiramate inhibits ROG by multiple mechanisms, including sodium channel modulation and enhancement of GABAergic activity. These actions collectively reduce neuronal excitability and gate opening.

Memantine hydrochloride

41100-52-1sc-203628
50 mg
$68.00
4
(2)

Memantine is an NMDA receptor antagonist that inhibits ROG by blocking excessive calcium influx through these receptors. It reduces excitotoxicity and downstream signaling, influencing gate function.

Riluzole

1744-22-5sc-201081
sc-201081A
sc-201081B
sc-201081C
20 mg
100 mg
1 g
25 g
$20.00
$189.00
$209.00
$311.00
1
(1)

Riluzole inhibits ROG by modulating glutamatergic neurotransmission. It reduces glutamate release and inhibits the activation of postsynaptic glutamate receptors, ultimately affecting gate mechanisms.