The term ROG Inhibitors refers to a class of chemical compounds designed to modulate the function of receptor-operated gates (ROGs) within biological systems. ROGs are specialized protein complexes that play a pivotal role in cellular communication and signal transduction processes. These gates consist of transmembrane proteins and ion channels regulating the flow of ions like calcium, sodium, and potassium across cell membranes. Their primary function is to control essential cellular processes, including neuronal excitation, muscle contraction, and secretion of signaling molecules.ROG inhibitors form a diverse group of chemical agents, each with a unique mechanism of action. These compounds are engineered to interfere with ROG operation, often by modulating ion channel activity or other crucial components.
ROG inhibitors act as calcium channel blockers, impeding calcium ions from entering cells, essential for signal transmission. Others may target specific receptor proteins, like NMDA receptors or GABA receptors, involved in ROG-mediated processes within the nervous system. By selectively binding or blocking these components, ROG inhibitors can finely regulate cellular responses, effectively controlling or dampening the signal transmission facilitated by these gates.The versatility of ROG inhibitors makes them invaluable tools for studying cellular physiology and signal transduction pathways. Researchers use these compounds to gain insights into the intricacies of ROG-mediated processes and their roles in various physiological contexts. By manipulating ROGs with inhibitors, scientists can dissect the underlying mechanisms of cellular communication, enabling a deeper understanding of fundamental biological processes. The primary purpose of ROG inhibitors lies in their utility as research agents for unraveling the complexities of cellular signaling networks.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits ROG by blocking L-type calcium channels, reducing calcium influx into cells, and subsequently preventing the activation of downstream signaling pathways involved in gate opening. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine, like nifedipine, is a calcium channel blocker that specifically targets L-type calcium channels, inhibiting ROG by reducing calcium entry and preventing gate activation. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine is a calcium channel blocker with a preference for cerebral blood vessels. It inhibits ROG by selectively blocking L-type calcium channels, preventing calcium influx and gate activation. | ||||||
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
Phenytoin inhibits ROG by stabilizing sodium channels, reducing neuronal excitability, and preventing excessive channel opening, ultimately affecting gate function. | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $118.00 $476.00 | 1 | |
Lamotrigine inhibits ROG by modulating voltage-gated sodium channels. It reduces excessive sodium influx into neurons, dampening excitability and gate activation. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
Gabapentin acts as a GABA analog and inhibits ROG by enhancing GABAergic inhibition. It indirectly inhibits neuronal excitation, reducing gate activation by modulating ion channel activity. | ||||||
Topiramate | 97240-79-4 | sc-204350 sc-204350A | 10 mg 50 mg | $105.00 $362.00 | ||
Topiramate inhibits ROG by multiple mechanisms, including sodium channel modulation and enhancement of GABAergic activity. These actions collectively reduce neuronal excitability and gate opening. | ||||||
Memantine hydrochloride | 41100-52-1 | sc-203628 | 50 mg | $68.00 | 4 | |
Memantine is an NMDA receptor antagonist that inhibits ROG by blocking excessive calcium influx through these receptors. It reduces excitotoxicity and downstream signaling, influencing gate function. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
Riluzole inhibits ROG by modulating glutamatergic neurotransmission. It reduces glutamate release and inhibits the activation of postsynaptic glutamate receptors, ultimately affecting gate mechanisms. | ||||||