RNF23 Inhibitors

E3 Ubiquitin-Protein Ligase TRIM39 (RNF23) inhibitors, as listed, target pathways and processes related to RNF23's function in ubiquitination, apoptosis, cell cycle regulation, and NF-kappa-B signaling. Given the complex nature of RNF23's roles, these inhibitors focus on modulating the broader cellular context and pathways in which RNF23 operates. Proteasome inhibitors like MG-132 [Z-Leu- Leu-Leu-CHO] and Bortezomib are included due to their ability to interfere with the ubiquitin-proteasome system, impacting RNF23's role in protein degradation. Nutlin-3, an MDM2 antagonist, could indirectly affect RNF23's interconnected role in the p53 pathway and CDKN1A/p21 regulation. MLN 4924, which inhibits NEDD8-activating enzyme, may also influence ubiquitination processes involving RNF23.

Compounds like Curcumin and Resveratrol, known for their modulation of NF-kappa-B signaling, are relevant due to RNF23's role in this pathway. PD 98059, an MEK inhibitor, and PD 0332991 hydrochloride, a CDK4/6 inhibitor, are included for their impact on cell cycle pathways where RNF23 is active. AZD7762, a CHK1 inhibitor, is pertinent for its role in DNA damage response and cell cycle regulation, processes in which RNF23 is involved. Piperlongumine, which can modulate apoptosis pathways, might intersect with RNF23's function in facilitating apoptosis. SP600125, a JNK inhibitor, is relevant for its influence on apoptosis and cell cycle pathways. IkB Kinase Inhibitors, targeting the NF-kappa-B signaling pathway, could also impact RNF23's regulatory role in this context. In summary, the strategy for targeting RNF23 involves influencing key cellular processes such as ubiquitination, apoptosis, cell cycle regulation, and NF-kappa-B signaling. These inhibitors, by modulating these pathways, offer a means to influence RNF23's activity, taking into account its complex role in various cellular functions.