RNF113A2 Inhibitors

RNF113A2 is a protein encoded by the RNF113A2 gene, which belongs to the RING finger protein family. RING finger proteins are characterized by the presence of a RING (Really Interesting New Gene) domain, a specialized type of zinc finger that typically functions as an E3 ubiquitin-protein ligase. These ligases are crucial components of the ubiquitin-proteasome system, a cellular pathway responsible for the regulation of protein degradation, which plays a significant role in maintaining protein homeostasis within the cell.The RNF113A2 protein, through its RING domain, is thought to mediate the ubiquitination of specific substrate proteins, tagging them for recognition and subsequent degradation by the 26S proteasome. This process is essential for controlling the levels of proteins within the cell and for the timely removal of misfolded, damaged, or regulatory proteins that have served their purpose.

In addition to its role in protein turnover, RNF113A2 may be involved in various cellular processes, including signal transduction, cell cycle regulation, and the response to stress or DNA damage. The ubiquitin-mediated modification of proteins by RNF113A2 can alter their activity, localization, or interaction with other molecules, thus influencing diverse cellular pathways.Mutations or dysregulation of the RNF113A2 gene, and by extension the RNF113A2 protein, have been implicated in certain genetic disorders and may contribute to the development of disease. The study of RNF113A2 and its interactions with other proteins in the cell provides valuable insights into the intricate network of protein regulation and its impact on cellular function and health.