RNase L Inhibitors
RNase L inhibitors comprise a diverse range of chemicals that may directly or indirectly modulate the activity of RNase L, an endoribonuclease involved in RNA degradation. Suramin, an RNA-processing enzyme inhibitor, can indirectly inhibit RNase L by interfering with RNA processing pathways. Actinomycin D and Actinomycin X2, inhibitors of transcription, reduce the availability of RNA substrates, indirectly modulating RNase L activity. 2-APB, an IP3R inhibitor, may indirectly inhibit RNase L by disrupting intracellular calcium signaling. Dicoumarol, inhibiting NQO1, influences the cellular redox state, impacting RNase L activation. Cisplatin, a DNA cross-linking agent, may indirectly inhibit RNase L by inducing genotoxic stress and altering pathways involved in RNase L regulation. Mefloquine, affecting calcium homeostasis, can modulate RNase L activation.
8-Bromo-cAMP, a synthetic cAMP analog, may indirectly inhibit RNase L by influencing cAMP-dependent pathways. Brefeldin A, an inhibitor of intracellular trafficking, can disrupt the proper localization and activation of RNase L. Tannic Acid, a polyphenolic compound, may indirectly inhibit RNase L by modulating cellular redox balance. Alpha-Amanitin, an RNA polymerase II inhibitor, indirectly modulates RNase L activity by disrupting RNA synthesis. In summary, these inhibitors present a multifaceted strategy to modulate RNase L by targeting diverse cellular processes and pathways. Understanding the specific biochemical and cellular mechanisms through which these inhibitors act on RNase L contributes to a more comprehensive knowledge of the regulatory networks governing this endoribonuclease. The intricate interplay between RNA processing, transcription, calcium signaling, redox balance, and intracellular trafficking provides avenues for further investigation into the modulation of RNase L activity and its role in cellular RNA degradation processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a polyanionic compound that inhibits various enzymes, including RNA-processing enzymes. It may indirectly inhibit RNase L by interfering with RNA processing pathways, impacting the substrate availability or function of RNase L in degrading RNA. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is an inositol trisphosphate receptor (IP3R) inhibitor that influences intracellular calcium signaling. Given the role of calcium in the activation of RNase L, inhibition of IP3R by 2-APB can indirectly modulate RNase L activity. The disruption of calcium signaling pathways involved in the activation of RNase L may lead to its inhibition, affecting the downstream RNA degradation processes that RNase L participates in. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $39.00 | 8 | |
quinone oxidoreductase 1 (NQO1). Its inhibition of NQO1 can indirectly influence the cellular redox state and the activation of RNase L, which is sensitive to cellular oxidative conditions. The modulation of RNase L activity by Dicoumarol may occur through its impact on the cellular redox environment, affecting the activation of RNase L and its downstream functions in RNA degradation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is a DNA cross-linking agent that may indirectly inhibit RNase L by inducing DNA damage. The activation of cellular stress responses, including those mediated by p53, can impact RNase L expression and function. Cisplatin-induced DNA damage may lead to alterations in the regulatory pathways involving RNase L, providing a potential mechanism for its inhibition in response to genotoxic stress. | ||||||
Mefloquine Hydrochloride | 51773-92-3 | sc-211784 | 100 mg | $116.00 | 4 | |
Mefloquine is an antimalarial drug that may indirectly inhibit RNase L through modulation of cellular calcium homeostasis. Its impact on intracellular calcium signaling pathways can influence the activation of RNase L. The disruption of calcium-dependent pathways involved in RNase L activation may lead to its inhibition, affecting the downstream RNA degradation processes that RNase L participates in. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP, a synthetic cAMP analog, may indirectly inhibit RNase L by influencing the cAMP-dependent pathways that regulate RNase L activity. The disruption of cAMP-mediated signaling pathways can modulate the activation of RNase L, potentially leading to its inhibition. The specific impact of 8-Bromo-cAMP on the cAMP-dependent regulation of RNase L provides a potential mechanism for its indirect inhibition of RNase L activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits protein transport between cellular compartments, impacting the endoplasmic reticulum (ER)-Golgi trafficking. Its influence on intracellular trafficking pathways can indirectly inhibit RNase L by disrupting its proper localization and activation. The altered subcellular distribution of RNase L caused by Brefeldin A may lead to its inhibition, affecting the downstream RNA degradation processes that RNase L is involved in. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $25.00 $36.00 $66.00 $76.00 $229.00 $525.00 $964.00 | 12 | |
Gallotannin is a polyphenolic compound with diverse biological activities. It may indirectly inhibit RNase L by affecting cellular redox balance and antioxidant defenses. The modulation of oxidative stress pathways by Tannic Acid can impact the activation of RNase L, leading to its potential inhibition. The specific influence of Tannic Acid on cellular redox mechanisms provides a potential mechanism for its indirect inhibition of RNase L activity. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin is a cyclic peptide toxin that inhibits RNA polymerase II, preventing transcription. By interfering with RNA synthesis, it indirectly inhibits RNase L by reducing the availability of RNA substrates. The disruption of RNA synthesis pathways by Alpha-Amanitin can impact the cellular processes regulated by RNase L, providing a potential mechanism for its inhibition. | ||||||