Dicoumarol is a reductase inhibitor possessing anticoagulant properties. Dicoumarol also aids in apoptosis induction via stimulation of SAPK-JNK and NF-κB pathway blocking. This has no effect on the phosphorylation of P38 or activation of AKT. Additionally, Dicoumarol has been shown to block brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells. Dicoumarol is an inhibitor of NQO1.
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Soluble in aqueous alkaline solutions, organic bases, 0.1 N NaOH (15 mg/ml), Pyridine (50 mg/ml), chloroform (slightly soluble), and benzene (slightly soluble). Insoluble in water, and alcohols.
How to dissolve Dicoumarol in DMSO quickly? I dissolved ~16 mg in 1 ml DMSO but it always precipitate although I already tried shaking and vortexing it.
Asked by: opik
Thank you for your question. We have not tested this in DMSO, but one suggestion would be to try gentle warming to bring it into solution.
Answered by: Technical Support
Date published: 2017-04-14
Is it possible dissolve Dicumarol in DMSO?
Asked by: Peng GONG
Thank you for your question. Dicumarol should be soluble in DMSO at 67mg/ml. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: [email protected] or by live chat directly on our website, www.scbt.com
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