RLD-1 Inhibitors
RLD-1 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of RLD-1, a protein thought to be involved in regulating gene expression, cell division, or cellular differentiation processes. RLD-1 is characterized by the presence of specific domains that allow it to interact with other proteins or DNA, making it a key component in several cellular regulatory pathways. Although the precise biological function of RLD-1 is not fully understood, it is believed to play a role in transcriptional regulation, possibly influencing the expression of genes critical for maintaining cellular homeostasis or controlling developmental processes. By inhibiting RLD-1, these compounds interfere with its regulatory functions, leading to changes in gene expression patterns or disrupting protein-protein interactions that are crucial for normal cellular function.
The design of RLD-1 inhibitors involves identifying key structural features of the protein, particularly its DNA-binding domains or interaction interfaces with other regulatory proteins. Inhibitors typically target these regions to block RLD-1 from interacting with its binding partners or from performing its transcriptional regulatory roles. Structural biology techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), and molecular docking studies are commonly used to map the active sites or binding pockets on RLD-1. This detailed structural information helps researchers develop inhibitors with high specificity for RLD-1, ensuring minimal off-target effects on other related proteins or cellular pathways. These inhibitors serve as valuable tools for exploring the function of RLD-1 in cellular processes such as gene regulation, cell division, and differentiation, providing insights into how this protein contributes to the overall regulatory networks within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW3965 | 405911-09-3 | sc-490151 sc-490151A sc-490151B | 10 mg 50 mg 1 g | $260.00 $872.00 $1637.00 | ||
GW3965 may initially activate RLD-1 but could ultimately lead to its downregulation by triggering a homeostatic response to suppress cholesterol biosynthesis genes. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole's inhibition of cytochrome P450 enzymes may lead to an accumulation of substrates that negatively feed back on the liver, diminishing RLD-1 expression in response to altered cholesterol metabolism. | ||||||
Guggulsterone | 95975-55-6 | sc-203990 sc-203990A | 10 mg 50 mg | $145.00 $615.00 | 1 | |
Guggulsterone, as an antagonist of certain nuclear receptors, could competitively bind to RLD-1, leading to decreased transcriptional activation of RLD-1 target genes involved in lipid metabolism. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
Prolonged exposure to T 0901317 might cause receptor desensitization and attenuate the expression of RLD-1 by decreasing the receptor's responsiveness to its natural ligands. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $162.00 $474.00 | 14 | |
By interfering with protein prenylation, geranylgeraniol could disrupt membrane localization and function of RLD-1, leading to reduced expression and lessened lipid-regulatory effects. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A might competitively interfere with endogenous RLD-1 ligands, resulting in a reduction of RLD-1 expression due to hindered ligand-receptor interactions. | ||||||
β-Sitosterol | 83-46-5 | sc-204432 sc-204432A | 10 g 25 g | $61.00 $217.00 | 5 | |
β-Sitosterol may compete with cholesterol, potentially lowering RLD-1 expression by disrupting normal cholesterol-sensing mechanisms that regulate gene transcription. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen, by serving as an antagonist to estrogen receptors, might also exert off-target effects that reduce RLD-1 expression, given the crosstalk between steroid hormone signaling pathways. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole could indirectly decrease RLD-1 expression by inhibiting the synthesis of mevalonate, a precursor for cholesterol which is a natural ligand for RLD-1. | ||||||
CHOLESTYRAMINE RESIN | 11041-12-6 | sc-507509 | 5 g | $210.00 | ||
Cholestyramine binds to and sequesters bile acids, which could lead to a compensatory decrease in RLD-1 expression as the body attempts to maintain cholesterol homeostasis. | ||||||