RIN3 Activators
RIN3 (Ras and Rab interactor 3) activators function through multiple biochemical mechanisms to promote its functional activity. Activation of adenylyl cyclase, for instance, leads to a rise in intracellular cAMP levels, thereby activating protein kinase A, which further influences downstream effectors that could include RIN3 as a target. This cascade of events is critical for the phosphorylation and potential activation of RIN3 mediated by secondary messengers. Furthermore, the engagement of certain cell surface receptors by their respective ligands triggers intracellular signaling pathways that converge on the Ras signaling pathway. These pathways facilitate the interaction between RIN3 and its associated GTPase substrates, promoting the GTP-bound active state of these GTPases, which is conducive to RIN3's guanine nucleotide exchange factor activity.
Additionally, modulation of intracellular kinase activity by specific compounds can impact RIN3's activity indirectly. For example, the activation of protein kinase C can phosphorylate substrates within RIN3's signaling network, thereby influencing RIN3-mediated endocytosis. Calcium ionophores that elevate intracellular calcium levels can initiate a cascade that activates calcium-dependent kinases, which in turn may modulate RIN3's function. Furthermore, the interplay between phosphatidylinositol 3-kinase (PI3K) and downstream effectors has a significant impact on RIN3's role in membrane trafficking and cytoskeletal dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This diterpene activates adenylyl cyclase, thereby increasing cyclic AMP (cAMP) levels in the cell. Elevated cAMP subsequently activates protein kinase A (PKA), which can lead to the phosphorylation and activation of RIN3 through secondary messengers. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
A non-hydrolyzable analog of GTP that can activate GTPases by preventing GTP hydrolysis. It indirectly activates RIN3 by maintaining GTPases in their active GTP-bound state, which are substrates for RIN3’s guanine nucleotide exchange factor (GEF) activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and thus modulate the activity of various downstream effectors, including those involved in RIN3-mediated endocytic pathways. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
A cAMP analog that activates PKA, leading to phosphorylation of downstream targets that could enhance RIN3-mediated signaling pathways. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
A potent inhibitor of PKA. By inhibiting PKA, it may lead to compensatory mechanisms that indirectly increase the activity of RIN3 as the cell attempts to restore balanced signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels, which could activate calcium-dependent kinases that modulate RIN3 activity indirectly. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels in the cell, leading to PKA activation. This cascade can phosphorylate substrates that are part of RIN3’s signaling network. | ||||||
Guanosine 5′-triphosphate trisodium salt | 36051-31-7 | sc-215111 sc-215111A | 10 mg 25 mg | $45.00 $70.00 | ||
The natural ligand for GTPases, it activates these proteins by binding to them. RIN3, with GEF activity, is indirectly activated through the enhancement of its substrate GTPases' activities. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P can bind to its G protein-coupled receptors, leading to the activation of downstream signaling cascades that may include RIN3-mediated endocytic trafficking. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA activates G protein-coupled receptors, leading to downstream signaling events that can intersect with RIN3’s role in endocytic processes. | ||||||