RIN1 Activators
RIN1 Activators represent a collection of chemicals that can indirectly enhance the activity of RIN1, a protein involved in various cellular signaling pathways. These chemicals act by modulating the EGFR, ERK, PI3K/AKT, mTOR, and CaMKII pathways, all of which have been shown to interact with or be affected by RIN1. For instance, EGF and Gefitinib, an EGFR activator and inhibitor respectively, can both lead to increased RIN1 activity through different mechanisms within the EGFR signaling pathway. Similarly, U0126 and PD98059, both MEK inhibitors, can enhance RIN1's inhibitory action on ERK activation.
On the other hand, LY294002 and Wortmannin, PI3K inhibitors, in conjunction with Triciribine and Perifosine, AKT inhibitors, can heighten RIN1's role in the PI3K/AKT pathway. Rapamycin, an mTOR inhibitor, can increase RIN1 activity by modulating the mTOR pathway. Lastly, KN-93, STO-609, and KN-62, inhibitors of CaMKII and CaMKK, indirectly bolster RIN1's interaction with CaMKII.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR inhibitor, which paradoxically can lead to an increase in RIN1 activity due to compensatory mechanisms in the EGFR signaling pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that blocks ERK activation. RIN1's inhibitory action on ERK can be enhanced through the inhibition of MEK. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. RIN1 has been shown to activate the PI3K/AKT pathway, so inhibition of PI3K can lead to an increase in RIN1 activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is a specific inhibitor of AKT, a downstream effector of PI3K. Blocking AKT can enhance RIN1's role in the PI3K/AKT pathway. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is a lipid-based AKT inhibitor. It interferes with AKT activation and can indirectly lead to increased RIN1 activity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Since RIN1 has been shown to interact with CaMKII, KN-93 can indirectly enhance RIN1's activity. | ||||||
STO-609 | 52029-86-4 | sc-507444 | 5 mg | $140.00 | ||
STO-609 is a selective and cell-permeable inhibitor of CaMKK. It can indirectly enhance RIN1 activity due to RIN1's interaction with CaMKII. | ||||||
KN-62 | 127191-97-3 | sc-3560 | 1 mg | $133.00 | 20 | |
KN-62 is a potent and specific inhibitor of CaMKII. By inhibiting this kinase, it can indirectly enhance RIN1 activity. | ||||||