RIM-BP2 Inhibitors
Chemical inhibitors of RIM-BP2 can exert their inhibitory effects through various mechanisms that involve the disruption of cytoskeletal dynamics and vesicle trafficking, both of which are essential for the function of RIM-BP2 in synaptic vesicle release. Phalloidin, for instance, binds and stabilizes actin filaments, preventing their remodeling which RIM-BP2 relies upon for modulating synaptic activity. Similarly, Latrunculin A sequesters actin monomers, and Cytochalasin D binds to the barbed ends of actin filaments, each leading to a destabilization of the actin cytoskeleton that RIM-BP2 utilizes. Jasplakinolide also stabilizes actin filaments, but does so in a way that locks them in a state incompatible with the synaptic vesicle mobilization that RIM-BP2 supports.
Additionally, Blebbistatin and ML-7 target myosin II and myosin light chain kinase (MLCK), respectively, both are key components in the contractile systems that contribute to vesicle movement, which is a process RIM-BP2 has been associated with. Y-27632's inhibition of Rho-associated protein kinase (ROCK) can lead to changes in actin regulation that indirectly impair RIM-BP2's associated synaptic functions. Wiskostatin and CK-636 both inhibit components of the actin polymerization machinery, with Wiskostatin inhibiting the N-WASP-Arp2/3 complex and CK-636 specifically targeting the Arp2/3 complex, which could impede the actin-related activities of RIM-BP2. Similarly, SMIFH2, by inhibiting formin-mediated actin filament formation, can disrupt the actin architecture needed for RIM-BP2's role. Finally, the microtubule-targeting agents Nocodazole and Colchicine can inhibit RIM-BP2 by interfering with microtubule-based transport systems, which are integral to the positioning and operational capabilities of RIM-BP2 at synaptic junctions.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds to actin filaments and stabilizes them, preventing the actin cytoskeleton remodeling that RIM-BP2 requires for synaptic vesicle release, thereby inhibiting RIM-BP2's role in synaptic function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts microfilament organization by sequestering actin monomers, indirectly inhibiting RIM-BP2 by disturbing the actin cytoskeleton dynamics essential for its synaptic functions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation, which is necessary for RIM-BP2-mediated synaptic vesicle exocytosis. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and prevents their disassembly, this can indirectly inhibit RIM-BP2 by locking the actin structure in a state that is not conducive to synaptic vesicle mobilization. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin inhibits myosin II ATPase activity, which could indirectly inhibit RIM-BP2 by impairing myosin's role in vesicle trafficking, a process RIM-BP2 is associated with at the synapse. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 inhibits myosin light chain kinase (MLCK), which in turn could inhibit RIM-BP2's function by reducing cytoskeletal dynamics necessary for its role in vesicle movement. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase (ROCK), which can indirectly inhibit RIM-BP2 by altering the actin cytoskeleton regulation and affecting synaptic vesicle dynamics linked to RIM-BP2. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin inhibits the N-WASP-Arp2/3 complex, which is involved in actin polymerization, potentially inhibiting RIM-BP2 by disrupting the actin architecture required for its synaptic function. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a formin inhibitor, which could inhibit RIM-BP2 indirectly by disrupting the formation of long actin filaments, thus affecting RIM-BP2's role in synaptic vesicle release. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which could inhibit RIM-BP2 indirectly by interfering with microtubule-based transport processes vital for the positioning and function of RIM-BP2 at the synapse. | ||||||