RHBDL2 Activators
The chemical activators associated with RHBDL2 predominantly influence the protein's activity indirectly by modulating endoplasmic reticulum (ER) stress and the Unfolded Protein Response (UPR). RHBDL2's localization in the ER means that alterations to this organelle's environment can have consequential impacts on its activity. Chemicals like Tunicamycin, Thapsigargin, and Dithiothreitol, among others, are known ER stress inducers. Tunicamycin, for instance, brings about ER stress by inhibiting N-linked glycosylation, thereby causing the accumulation of unfolded proteins. This accumulation can subsequently activate RHBDL2 as the cell seeks to degrade these misfolded proteins and restore homeostasis. Similarly, Thapsigargin causes a surge in intracellular calcium levels, which can have a cascading effect, leading to ER stress and activation of RHBDL2.
Furthermore, chemicals like Brefeldin A disrupt the function of the Golgi apparatus, causing protein traffic jams that can also induce ER stress. On the other hand, chemicals like Tauroursodeoxycholic acid (TUDCA) and 4-Phenylbutyrate (4-PBA) are known to reduce ER stress. However, their interplay with other chemicals inducing ER stress can have a fine-tuning effect on RHBDL2 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress, which can indirectly activate RHBDL2 to degrade misfolded proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Elevates intracellular calcium levels, inducing ER stress and leading to RHBDL2 activation. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Induces ER stress by inhibiting glycosylation, which can activate RHBDL2. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Induces ER stress by disrupting Golgi apparatus function, potentially leading to RHBDL2 activation. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Reduces ER stress, but its balance with other ER stress inducers can modulate RHBDL2 activity. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Chemical chaperone that reduces ER stress but can modulate RHBDL2 in conjunction with other ER stress inducers. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Inhibits ER-associated degradation (ERAD) and can induce ER stress, leading to RHBDL2 activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases calcium levels, inducing ER stress, which can activate RHBDL2. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Inhibits dephosphorylation of eIF2α leading to ER stress, potentially activating RHBDL2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore that can induce ER stress, potentially leading to RHBDL2 activation. | ||||||