RGS8 Inhibitors
RGS8 inhibitors as a chemical class are not defined by a common structure or specific binding interaction with the RGS8 protein. Instead, they encompass a range of compounds that may impact the signaling pathways where RGS8 functions. RGS proteins, including RGS8, serve as GTPase-activating proteins (GAPs) for G alpha subunits, thus turning off G protein-coupled receptor (GPCR) signaling pathways. Any chemical that can modulate the function of these G proteins, either through direct inhibition, altering their expression, or interfering with their post-translational modifications, may have an indirect influence on RGS8 activity.
The listed chemicals primarily target kinases, phosphatases, or other proteins that are involved in the signaling cascades downstream or upstream of GPCR pathways. These compounds, while not interacting with RGS8 directly, can modify the cellular signaling context, which in turn may alter the activity of RGS8. For instance, kinase inhibitors such as Y-27632 or PD 98059 may disrupt the phosphorylation status of proteins within GPCR pathways, potentially influencing RGS8's ability to regulate G protein signaling. Similarly, compounds like LY294002 or Wortmannin that inhibit PI3K can impact a multitude of signaling pathways that could indirectly modulate RGS8 function. It is through these various actions on the cellular signaling network that these compounds can affect the regulation of GPCR pathways by RGS8
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A selective inhibitor of ROCK (Rho-associated protein kinase), which is involved in the regulation of G proteins. RGS8 modulates G protein activity; thus, inhibiting ROCK can attenuate RGS8-mediated signaling pathways. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Interferes with Gβγ signal transduction, which is an integral part of G protein-coupled receptor (GPCR) function, and by extension, RGS8 activity, as it acts on these pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor, which can affect ERK pathway downstream of GPCR signaling, potentially modifying the activity of RGS8 indirectly by altering G protein signaling dynamics. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A potent PKC inhibitor, with PKC being a kinase that can phosphorylate various proteins involved in GPCR pathways. RGS8, being associated with GPCR signaling, can be indirectly affected by this compound. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
A broad-spectrum PKC inhibitor that can modify signaling cascades in which RGS8 is a participant, thereby altering its function in an indirect manner. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
An inhibitor of p38 MAPK, a kinase involved in inflammatory and stress response pathways. This kinase can interact with GPCR signaling, which is modulated by RGS8, thus potentially affecting RGS8's role indirectly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, which is important in a wide range of cellular functions. Since PI3K pathways can crosstalk with GPCR signaling, inhibition of PI3K can have downstream effects on RGS8's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor with a similar mode of action to LY294002, potentially affecting RGS8 indirectly through alterations in GPCR-related signaling. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
An inhibitor of various growth factors and receptors. It has complex effects on cell signaling and could influence GPCR pathways and thus indirectly modulate RGS8 function. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
A selective inhibitor of PKC, which can have a broad impact on cell signaling, including pathways that involve RGS8. | ||||||