RGL3 Activators
RGL3 operate through various biochemical pathways to modulate its activity. Phorbol 12-myristate 13-acetate (PMA) and Phorbol 12,13-dibutyrate (PDBu) are both activators of protein kinase C (PKC). Upon activation, PKC can phosphorylate RGL3, a modification that alters the function of RGL3, integrating it into phospholipid signaling pathways. Forskolin, by stimulating adenylyl cyclase, enhances the production of cAMP, which can activate protein kinase A (PKA). PKA, in turn, can phosphorylate RGL3, thereby participating in cAMP-dependent signaling mechanisms. Similarly, Isoproterenol, through beta-adrenergic receptor signaling, can elevate cAMP levels, leading to the activation of PKA, which then phosphorylates RGL3, further illustrating the versatility of cAMP-mediated pathways in the regulation of RGL3.
Ionomycin, as a calcium ionophore, raises intracellular calcium levels, potentially activating calmodulin-dependent kinases that may phosphorylate RGL3. This places RGL3 within the broader context of calcium signaling pathways. Epidermal Growth Factor (EGF) engages its receptor, setting off a phosphorylation cascade capable of incorporating RGL3 into cell growth signaling networks. Anisomycin, a stress response mediator, activates stress-activated protein kinases (SAPKs) that could phosphorylate RGL3, reflecting the protein's role in cellular stress responses. Hydrogen Peroxide, through modulation of tyrosine kinase activity, can integrate RGL3 into redox signaling pathways via phosphorylation events. Lastly, S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide that activates guanylyl cyclase, increasing cGMP levels, which may lead to the activation of kinases that phosphorylate RGL3. This illustrates the influence of nitric oxide signaling on the regulation of RGL3 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which in turn could activate RGL3 by phosphorylating it or associated proteins, thereby altering its activity and promoting its role in signal transduction cascades. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, resulting in increased production of cAMP, which may activate PKA. PKA could then phosphorylate RGL3 or related regulatory proteins, leading to RGL3 activation as part of the cAMP-dependent signaling pathway. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a cytidine analog, is incorporated into RNA and can disrupt normal cellular methylation. This disruption may lead to changes in the methylation status of proteins interacting with RGL3, which could result in the activation of RGL3 through allosteric modulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium levels can activate calmodulin-dependent kinases, which may phosphorylate and activate RGL3 as part of calcium signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can stimulate adenylyl cyclase through G-protein-coupled receptor signaling, leading to increased cAMP levels. This rise in cAMP may activate PKA, which could then phosphorylate and activate RGL3. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide can act as a signaling molecule that modulates tyrosine kinase activity. This modulation can lead to the activation of signaling cascades that phosphorylate and activate RGL3, thereby integrating RGL3 into redox signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs). These SAPKs may phosphorylate and activate RGL3 as part of the cellular stress response. | ||||||
Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | sc-203279 sc-203279A | 5 g 10 g | $82.00 $120.00 | 9 | |
S-Nitroso-N-acetylpenicillamine (SNAP) releases nitric oxide, which can activate guanylyl cyclase, leading to increased cGMP levels. The rise in cGMP could activate protein kinases that phosphorylate and activate RGL3 as part of nitric oxide signaling pathways. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
Phorbol 12,13-dibutyrate (PDBu) is a PKC activator that can mimic diacylglycerol. Activated PKC may phosphorylate RGL3, resulting in its activation within phospholipid signaling pathways. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
1,2-Dioctanoyl-sn-glycerol (DiC8) is a synthetic analog of diacylglycerol that can activate PKC. Once PKC is activated, it may phosphorylate RGL3, leading to its activation in signaling pathways that involve lipid second messengers. | ||||||