RGC32 Activators
RGC32 activators encompass a diverse set of chemical compounds that indirectly bolster the functional activity of RGC32 through a variety of signaling pathways. Compounds such as Forskolin and Dibutyryl-cAMP increase intracellular cAMP levels, activating PKA, which could enhance RGC32 phosphorylation and activity regarding cell cycle regulation and T cell activation. PMA and Ionomycin, through their roles as activators of PKC and calcium ionophores respectively, may influence RGC32 by modifying phosphorylation patterns and calcium-dependent signaling processes, thereby promoting RGC32's involvement in cellular differentiation, proliferation.
RGC32 activators comprise a spectrum of chemical entities that indirectly enhance the functional activity of RGC32 by interfacing with various signaling pathways intrinsic to cellular physiology. Forskolin, by increasing intracellular cAMP, and Isoproterenol, through beta-adrenergic receptor stimulation, activate PKA, which could potentially phosphorylate RGC32, thus enhancing its activity in processes such as cell cycle regulation and T cell activation. Similarly, the cAMP analog Dibutyryl-cAMP promotes PKA activation, suggesting a supportive role in RGC32's function in immune response modulation. PMA's activation of PKC and the calcium ionophores Ionomycin and A23187's elevation of intracellular calcium may also contribute to RGC32's enhanced activity, influencing cellular differentiation and response to stress. Additionally, lysophosphatidic acid (LPA) through G protein-coupled receptor signaling, and Sphingosine-1-phosphate through sphingolipid signaling, offer routes to potentiate RGC32's role in cytoskeletal reorganization and cell migration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels which in turn activate PKA. PKA can then phosphorylate various substrates that may include RGC32, thereby enhancing RGC32's activity in cell cycle regulation and T cell activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which could phosphorylate RGC32 or associated proteins, leading to the enhanced activity of RGC32 in cellular signaling pathways such as those involved in differentiation and proliferation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin functions as a calcium ionophore, elevating intracellular calcium levels, which could activate calcineurin or other calcium-dependent proteins that subsequently enhance the function of RGC32 in cell cycle progression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol acts as an agonist for beta-adrenergic receptors, leading to increased cAMP and activation of PKA. PKA may enhance RGC32 phosphorylation status, thus promoting RGC32's role in cellular growth signaling. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysophosphatidic acid (LPA) activates G protein-coupled receptors, triggering downstream signaling cascades that may affect RGC32's activity in cytoskeletal organization and cell migration. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate works through G protein-coupled receptors to influence cell survival pathways that could overlap with RGC32's functions in apoptosis regulation and angiogenesis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium storage and increases cytosolic calcium levels, possibly activating pathways that enhance RGC32's role in cell proliferation and stress responses. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, similarly to Ionomycin, raising intracellular calcium and potentially enhancing RGC32's activity through calcium-dependent signaling pathways in cell growth and differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA, potentially enhancing RGC32's activity involved in the regulation of cell cycle checkpoints and immune cell activation. | ||||||