RGAG4 Inhibitors
Inhibitors of RGAG4 function by specifically targeting signaling pathways and cellular processes that are integral to the protein's activity. Certain inhibitors exert their effects by interfering with kinase signaling cascades, such as protein kinase C, which plays a role in post-translational modifications that regulate RGAG4. The inhibition of key kinases can lead to the dephosphorylation and subsequent inactivation of RGAG4, as well as the suppression of other related signaling pathways. For instance, the targeting of the mTOR pathway can impair downstream signaling, leading to a reduction in RGAG4 activity. Similarly, the blockade of the PI3K/Akt and MAPK/ERK pathways through selective inhibitors can diminish the phosphorylation state and activity of downstream targets, including RGAG4. These inhibitors are designed to disrupt specific signaling events, which in turn can indirectly suppress the functional activity of RGAG4.
Moreover, other inhibitors can induce a cellular environment that is detrimental to RGAG4 function. Proteasome inhibitors, for example, lead to the accumulation of misfolded proteins, which can disrupt the protein homeostasis within the cell and indirectly affect RGAG4 function. Inhibitors that target cell cycle regulators, such as Aurora kinases and cyclin-dependent kinases, may alter cell cycle progression and mitotic events, potentially decreasing RGAG4 activity if it is related to these processes. In addition, molecules that modulate the p53 pathway can induce cell cycle arrest or apoptosis, which in turn could result in diminished RGAG4 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can suppress protein kinase C, which is involved in the transduction of signals that may regulate the activity of RGAG4 by post-translational modifications, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can lead to the dephosphorylation and inactivation of downstream targets, potentially resulting in the reduced activity of RGAG4 due to impaired signaling within the mTOR pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that may disrupt the PI3K/Akt pathway, diminishing the phosphorylation and activity of downstream proteins, which could indirectly reduce RGAG4 activity through altered cellular signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor that can prevent the activation of the MAPK/ERK pathway, potentially leading to decreased functional activity of RGAG4 by affecting its regulatory mechanisms within this signaling cascade. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which could impair the JNK signaling pathway, potentially affecting the activity of RGAG4 if the protein's function is modulated through this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that may inhibit the p38 MAPK pathway, leading to a reduction in the functional activity of downstream targets including RGAG4, if it is regulated by this signaling route. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2 which can block the MAPK/ERK pathway, potentially diminishing RGAG4 activity through the disruption of its associated signaling processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, potentially affecting RGAG4 function by disrupting the proteostatic environment of the cell. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor that could affect the cell cycle and mitotic spindle formation, potentially leading to altered RGAG4 activity if it plays a role in cell cycle regulation or chromosome segregation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
An irreversible PI3K inhibitor that can disrupt the PI3K/Akt signaling pathway, potentially leading to indirect inhibition of RGAG4 activity through changes in downstream signaling. | ||||||