RFRP-3 Activators
RFRP-3 activators constitute a class of chemical agents that target and modulate the activity of the RFamide-related peptide-3 (RFRP-3), a member of the RFamide family of peptides. RFRP-3 is an intriguing protein that has been identified as playing a role in the regulation of neuroendocrine functions. It is found in the precursor polypeptide prepro-GnIH and is expressed in various tissues, including the central nervous system.
The activators of RFRP-3 can operate through direct or indirect pathways. Direct activators may interact with the peptide or its receptor, enhancing its ability to bind and signal through the associated G protein-coupled receptors (GPCRs). This could involve an increase in the peptide's stability, an alteration of its conformation to a more active state, or a facilitation of its interaction with the receptor. Indirect activators, on the other hand, might increase the expression levels of RFRP-3 or its receptor, augment signal transduction pathways downstream of the receptor, or affect the release of RFRP-3 from neurons. Research into RFRP-3 activators is a vibrant field that aims to dissect the complex interplay between neuroendocrine signaling molecules and their regulatory mechanisms. The study of these activators provides insights into the modulation of RFRP-3 and its receptor's signaling pathways, which can have significant implications for understanding neuroendocrine regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase, which enhances cAMP levels and PKA activity. By boosting cAMP signaling, it may indirectly upregulate RFRP-3, involved in cAMP mediated neuronal signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of phosphodiesterase 4 (PDE4), thereby enhancing cAMP levels. It could indirectly enhance RFRP-3 expression via cAMP-dependent pathway in neurons. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A membrane-permeable cAMP analog that can enhance cAMP-dependent signaling, potentially upregulating RFRP-3 in neuronal cells. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, part of the MAPK pathway. It may affect RFRP-3 expression via MAPK-related signaling in neurons. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, influencing the Akt pathway. By modulating this pathway, it may indirectly affect RFRP-3 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK, part of the MAPK pathway. It may indirectly influence RFRP-3 expression in neurons. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor, which could potentially influence RFRP-3 expression via the MAPK signaling pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An inhibitor of mTOR, affecting protein synthesis and cell growth. It may indirectly affect RFRP-3 expression via the mTOR pathway. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
An inhibitor of CaMKII, which plays a role in many cellular processes including neuroplasticity. It may indirectly affect RFRP-3 expression via the CaMKII pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An inhibitor of NF-kB activation, which may indirectly modulate RFRP-3 expression through NF-kB related pathways. | ||||||