RERGL Activators
Chemical activators of RERGL can engage in a series of cellular events that lead to the protein's activation through the modulation of the cAMP signaling pathway. Forskolin, by directly activating adenylate cyclase, increases cAMP levels within the cell. This rise in cAMP facilitates the activation of Protein Kinase A (PKA), which then phosphorylates RERGL, leading to its activation. Similarly, Isoproterenol, a beta-adrenergic agonist, and Terbutaline, a beta2-adrenergic agonist, also bind to their respective receptors, initiating a cascade that results in adenylate cyclase stimulation. The consequent elevation of cAMP activates PKA, which can phosphorylate RERGL. On the other hand, IBMX acts as a non-selective inhibitor of phosphodiesterases, preventing the degradation of cAMP and thereby sustaining its presence and the subsequent activation of PKA, which then acts on RERGL.
Further contributing to the regulation of RERGL are compounds that influence cAMP levels through various receptor-mediated mechanisms. Epinephrine and Dopamine achieve this by binding to adrenergic and dopaminergic receptors, respectively, each promoting adenylate cyclase activity and enhancing cAMP production. Adenosine and PGE2 similarly interact with their specific G protein-coupled receptors to activate adenylate cyclase, thereby increasing cAMP and activating PKA, which in turn phosphorylates RERGL. Histamine, through interaction with H2 receptors, also leads to increased cAMP levels and PKA activation. Cholera Toxin, by permanently activating Gs alpha protein, causes a sustained increase in adenylate cyclase activity, and thus cAMP levels, leading to continuous PKA activity and RERGL activation. Lastly, Anagrelide and Rolipram, by inhibiting PDE3 and PDE4 respectively, prevent the breakdown of cAMP, again leading to an accumulation of active PKA and subsequent phosphorylation of RERGL. Each of these chemical activators, by modulating different components of the cAMP signaling pathway, can contribute to the activation of RERGL within the cellular environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that binds to beta receptors, stimulating adenylate cyclase and increasing cAMP levels. This activation of the cAMP pathway results in the activation of PKA, which could phosphorylate RERGL, leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX (3-Isobutyl-1-methylxanthine) is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP, thereby maintaining its levels within the cell. High levels of cAMP facilitate PKA activation, which in turn can activate RERGL. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with adrenergic receptors, stimulating adenylate cyclase to produce cAMP. The resultant increase in cAMP levels activates PKA, which is known to phosphorylate and activate proteins such as RERGL in the cAMP signaling pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, by binding to its G protein-coupled receptors, can also stimulate adenylate cyclase activity, leading to increased cAMP and activation of PKA. PKA then potentially phosphorylates and activates RERGL. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G protein-coupled EP receptors, which can stimulate adenylate cyclase activity. The rise in cAMP level subsequently activates PKA, which may phosphorylate and activate RERGL. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with its G protein-coupled receptors to activate adenylate cyclase, increasing intracellular cAMP concentration. This elevation leads to activation of PKA that could activate RERGL through phosphorylation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 receptors which are coupled to adenylate cyclase activation via Gs protein, leading to an increase in cAMP levels and subsequent activation of PKA. PKA may then phosphorylate and activate RERGL. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that can stimulate adenylate cyclase, resulting in elevated cAMP levels. This activates PKA, which could lead to the phosphorylation and activation of RERGL. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide inhibits phosphodiesterase III (PDE3), resulting in increased cAMP levels. This accumulation of cAMP can activate PKA which, in turn, may phosphorylate and activate RERGL. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram specifically inhibits PDE4, leading to increased cAMP levels within the cell. The enhanced cAMP levels lead to PKA activation, which subsequently could phosphorylate and activate RERGL. | ||||||