REDD-2 Activators
REDD-2 activators are chemicals that either directly activate the DNA damage-inducible transcript 4-like protein or interact with cellular pathways to modulate its activity. These activators are understood through the lens of cellular metabolism and energy regulation. The activation of REDD-2 is closely tied to the cellular energy state, and thus compounds that are involved in the modulation of energy sensing, and stress response pathways naturally intersect with the regulation of REDD-2 activity. Among these, AMPK is a critical sensor and regulator of cellular energy homeostasis, and several compounds that activate REDD-2 do so by first activating AMPK. This provides a molecular link between the presence of these compounds and the subsequent activation of REDD-2.
The biochemical pathways involved with these activators are complex and interwoven. The compounds that indirectly influence REDD-2 do so by modulating the activity of AMPK or other related sensors and mediators of cellular energy and nutrient status, such as mTOR and SIRT1. These activators work by initiating a chain of intracellular events or by influencing the expression of genes that control energy balance and stress response. Such compounds do not work in isolation but are part of a broader cellular signaling context, which ensures that the activation of REDD-2 is a regulated process, integrated with the cell's overall function and state.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000 sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E | 1 g 5 g 10 g 50 g 100 g 250 g | $30.00 $42.00 $62.00 $153.00 $255.00 $500.00 | 37 | |
This compound activates AMP-activated protein kinase (AMPK), which in turn can upregulate REDD-2. Activation of AMPK by Metformin leads to a cascade of cellular energy balance responses that include the upregulation of REDD-2 as part of the cellular energy homeostasis mechanism. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMPK activator. By activating AMPK, AICAR promotes the phosphorylation and subsequent activation of REDD-2, as REDD-2 is a downstream target of AMPK involved in maintaining energy balance within the cell. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate sirtuin 1 (SIRT1), which can indirectly activate REDD-2 by modulating the NAD+/NADH ratio and thus influencing AMPK activity. Increased SIRT1 activity through resveratrol supplementation can enhance the cellular energy stress response, including the activation of REDD-2. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine can activate the mammalian target of rapamycin (mTOR) pathway. This activation can modulate REDD-2 levels indirectly since mTOR is a nutrient sensor whose activity is associated with REDD-2 expression under certain cellular conditions. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine promotes autophagy through inhibition of the acetyltransferase EP300. Enhanced autophagy is associated with increased activity of REDD-2, as this protein is involved in cellular responses to nutrient availability and energy stress. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can activate the Wnt/β-catenin signaling pathway, which has been shown to cross-talk with REDD-2 expression. Activation of this pathway can result in the stabilization of cellular energy homeostasis mechanisms in which REDD-2 plays a part. | ||||||
β-Hydroxyisovaleric acid | 625-08-1 | sc-235338 | 5 g | $490.00 | ||
HMB can enhance protein synthesis via the mTOR pathway. This may indirectly upregulate REDD-2 as part of the cellular growth and energy regulation response. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylate can activate AMPK, which is a key regulator of cellular energy homeostasis and can lead to the activation of REDD-2. Through AMPK activation, salicylate influences cellular metabolism pathways that are also regulated by REDD-2. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates AMPK, which in turn can activate REDD-2 by promoting cellular energy balance. Berberine's action on AMPK therefore indirectly supports the activation of REDD-2 as a response to metabolic stress. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is reported to activate AMPK and can thus enhance the activity of REDD-2 as part of the AMPK signaling pathway that responds to changes in cellular energy status. | ||||||