RCOR2 Inhibitors

RCOR2 Inhibitors is a chemical class of compounds that primarily target the Reversing Cofactor of RE1 (RCOR2) protein, also known as CoREST2. These inhibitors are predominantly utilized in the field of molecular biology and epigenetics for research purposes. RCOR2, as a core component of the CoREST complex, plays a pivotal role in epigenetic regulation and gene expression control. Inhibitors within this class are designed to interfere with the normal function of RCOR2, ultimately modulating the epigenetic landscape of cells and influencing gene transcription.

The mechanisms of action for RCOR2 inhibitors are diverse and multifaceted. Some of these compounds may act as histone deacetylase (HDAC) inhibitors, preventing the removal of acetyl groups from histones. This leads to increased histone acetylation, a hallmark of transcriptionally active chromatin, and subsequently promotes gene expression. Other RCOR2 inhibitors may function by targeting DNA methyltransferases, causing alterations in DNA methylation patterns. By reducing DNA methylation, these inhibitors can activate genes that were previously silenced. Additionally, some compounds within this class may disrupt protein-protein interactions between RCOR2 and transcription factors, preventing the recruitment of RCOR2 to specific gene promoters and thereby influencing gene regulation