RBQ-1 Inhibitors
Chemical inhibitors of RBQ-1 can exert their effects through various mechanisms that interfere with cellular processes. Paclitaxel, for instance, stabilizes microtubules and thereby prevents their disassembly. This action can thwart mitotic spindle formation and cell division, leading to cell death. Since RBQ-1 is involved in cell cycle regulation, paclitaxel's prevention of cellular progression can indirectly inhibit the function of RBQ-1. Similarly, Nutlin-3, by binding to MDM2, disrupts its interaction with p53, which can lead to the stabilization of p53's tumor suppressor activity. Given the interplay between RBQ-1 and the p53 pathway, this stabilization of p53 can curb the regulatory influence of RBQ-1 on p53. MG-132, another inhibitor, targets the proteasomal degradation pathway, causing an accumulation of ubiquitinated proteins and potentially hampering several RBQ-1 regulated cellular processes, inducing cell cycle arrest and cell death.
Moreover, Z-VAD-FMK, a broad-spectrum caspase inhibitor, can prevent apoptosis, a process in which RBQ-1 is implicated. By blocking caspase activity, Z-VAD-FMK could interrupt the downstream effects of RBQ-1 in the apoptotic signaling pathway. Trichostatin A and Vorinostat are histone deacetylase (HDAC) inhibitors that alter chromatin structure, which may impact the role of RBQ-1 in gene expression regulation. Bortezomib, like MG-132, is a proteasome inhibitor that leads to the buildup of proteins destined for degradation, which may include those regulated by RBQ-1, again leading to cell cycle arrest and cell death. Alisertib's inhibition of Aurora kinase A can disrupt mitotic processes, thereby functionally inhibiting RBQ-1 if it is implicated in these processes. Palbociclib, which inhibits CDK4/6, leads to G1 phase cell cycle arrest, potentially halting the cell cycle at a juncture where RBQ-1 is functionally important. Auranofin influences the redox state within the cell, affecting signaling pathways, including those of apoptosis where RBQ-1 may be active. Olaparib, a PARP inhibitor, impedes DNA repair mechanisms, which could affect RBQ-1's role in DNA damage response. Lastly, Venetoclax, which selectively inhibits Bcl-2, can activate apoptotic pathways that may be modulated by RBQ-1, thereby suppressing its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can disrupt mitotic spindle formation and cell division, leading to apoptosis. Since RBQ-1 is implicated in cell cycle regulation, paclitaxel's action on microtubules leads to functional inhibition of RBQ-1 by preventing cellular progression where RBQ-1 might be required. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 binds to MDM2, inhibiting its interaction with p53. As RBQ-1 is known to interact with the p53 pathway, Nutlin-3's stabilization of p53 can enhance p53's tumor suppressor function, thereby inhibiting RBQ-1's role in p53 regulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins, disrupting various cellular processes including those regulated by RBQ-1, ultimately leading to cell cycle arrest and apoptosis. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK is a broad-spectrum caspase inhibitor that can prevent apoptosis. Since RBQ-1 is involved in apoptotic signaling, inhibiting caspases can interrupt the downstream effects of RBQ-1 activity in the apoptosis pathway. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDAC). As RBQ-1 has been associated with chromatin modification due to its interaction with p53, inhibiting HDAC can alter the chromatin state and thereby inhibit RBQ-1's role in gene expression regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is another HDAC inhibitor, similar to Trichostatin A, which can modify the chromatin structure and indirectly inhibit RBQ-1's ability to modulate gene expression through chromatin remodeling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor like MG-132, inhibiting the degradation of ubiquitin-tagged proteins, which may include substrates regulated by RBQ-1, leading to cell cycle arrest and potential apoptosis. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase A inhibitor, and since Aurora kinases are key regulators of mitosis, inhibiting them could disrupt cell division processes where RBQ-1 might play a role, therefore functionally inhibiting RBQ-1. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor that leads to G1 phase cell cycle arrest. If RBQ-1 is involved in cell cycle progression, inhibiting CDK4/6 would halt the cell cycle at a point that could functionally inhibit RBQ-1. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin is an inhibitor of thioredoxin reductase, and by altering the redox state within the cell, it can influence various signaling pathways, including those involving apoptosis where RBQ-1 may be implicated, leading to its functional inhibition. | ||||||