RasGRP1 Inhibitors
RasGRP1 inhibitors represent a diverse array of chemicals that have the ability to modulate the activity of RasGRP1, a crucial signaling protein involved in Ras-mediated cellular responses. These inhibitors, while not directly interacting with RasGRP1, exert their effects through indirect mechanisms, targeting various signaling pathways and cellular processes that intersect with RasGRP1 activation. Calphostin C, a potent protein kinase C (PKC) inhibitor, indirectly influences RasGRP1 by modulating PKC-dependent signaling pathways. PKC is known to interact with RasGRP1, affecting its activity and downstream signaling cascades. Similarly, NSC 23766, a Rac1 inhibitor, indirectly impacts RasGRP1 by targeting Rac1-mediated signaling pathways, which intersect with Ras signaling and may modulate RasGRP1 activity. CID 1067700, a RAC1 inhibitor, indirectly affects RasGRP1 by modulating RAC1-mediated signaling pathways, influencing RasGRP1 activity and downstream cellular responses. BAY 61-3606, a Syk kinase inhibitor, indirectly influences RasGRP1 by affecting Syk-mediated signaling pathways, which intersect with Ras signaling and may modulate RasGRP1 activity.
AZD 8330, a MEK inhibitor, indirectly impacts RasGRP1 by targeting the MEK/ERK pathway downstream of Ras signaling, thereby modulating RasGRP1 activity and downstream cellular responses. Manumycin A, an inhibitor of Ras farnesyltransferase, disrupts the farnesylation process of Ras, indirectly influencing RasGRP1 function and downstream signaling cascades. BI-D1870, a selective RSK inhibitor, indirectly influences RasGRP1 by affecting RSK-mediated signaling pathways that intersect with Ras signaling. CID 44216842, a RasGRP3 inhibitor, indirectly impacts RasGRP1 by influencing the overall balance of RasGRP isoforms and their possible crosstalk. AZD 5438, a CDK1/2 inhibitor, indirectly influences RasGRP1 by affecting CDK-mediated signaling pathways that intersect with Ras signaling. In summary, these diverse RasGRP1 inhibitors offer valuable tools for researchers studying Ras signaling pathways, providing insights into the intricate network of cellular processes influenced by RasGRP1 activity. Their indirect mechanisms of action highlight the complexity of RasGRP1 regulation and its interconnectedness with various signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C is a potent inhibitor of protein kinase C (PKC). Indirectly, it may influence RasGRP1 by modulating PKC-dependent signaling pathways, affecting cellular processes that intersect with RasGRP1 activation and downstream effects. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
GDC-0941 is a potent inhibitor of phosphoinositide 3-kinase (PI3K). Indirectly, it may impact RasGRP1 by affecting the PI3K/AKT pathway, which intersects with Ras signaling, thereby influencing RasGRP1 activity and downstream cellular responses. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib is a multi-kinase inhibitor targeting Raf kinases. As RasGRP1 is upstream of Raf in the Ras signaling pathway, Sorafenib may indirectly inhibit RasGRP1 by modulating Raf kinase activity and downstream signaling events, influencing RasGRP1-mediated cellular responses. | ||||||
2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic Acid | 314042-01-8 | sc-503400 | 10 mg | $300.00 | ||
Also called CID 1067700, this compound is an inhibitor of Ras-related C3 botulinum toxin substrate 1 (RAC1). By targeting RAC1, CID 1067700 indirectly affects RasGRP1 by modulating RAC1-mediated signaling pathways, potentially influencing RasGRP1 activity and downstream cellular responses. | ||||||
BAY 61-3606 | sc-507485 | 2 mg | $345.00 | 1 | ||
BAY 61-3606 is an inhibitor of Syk kinase. While not directly targeting RasGRP1, BAY 61-3606 may influence RasGRP1 indirectly by affecting Syk-mediated signaling pathways, which intersect with Ras signaling and may modulate RasGRP1 activity and downstream cellular responses. | ||||||
AZD8330 | 869357-68-6 | sc-364425 sc-364425A | 5 mg 10 mg | $255.00 $450.00 | ||
AZD 8330 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MEK). Indirectly, it may impact RasGRP1 by targeting the MEK/ERK pathway, which is downstream of Ras signaling, thereby influencing RasGRP1 activity and downstream cellular responses. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is an inhibitor of Ras farnesyltransferase. As RasGRP1 requires proper prenylation for its activity, Manumycin A indirectly influences RasGRP1 by disrupting the farnesylation process of Ras, affecting RasGRP1 function and downstream signaling cascades. | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | $92.00 $260.00 | 12 | |
BI-D1870 is a selective inhibitor of ribosomal S6 kinase (RSK). While not directly targeting RasGRP1, BI-D1870 may influence RasGRP1 indirectly by affecting RSK-mediated signaling pathways, which intersect with Ras signaling and may modulate RasGRP1 activity and downstream cellular responses. | ||||||
CID-44216842 | 1222513-26-9 | sc-507406 | 5 mg | $285.00 | ||
CID 44216842 is an inhibitor of Ras guanine nucleotide-releasing protein 3 (RasGRP3). By targeting RasGRP3, it indirectly impacts RasGRP1 by affecting the overall balance of RasGRP isoforms and their potential crosstalk, thereby modulating RasGRP1-mediated cellular responses. | ||||||
AZD 5438 | 602306-29-6 | sc-361115 sc-361115A | 10 mg 50 mg | $205.00 $865.00 | ||
AZD 5438 is a potent inhibitor of cyclin-dependent kinase 1 (CDK1) and cyclin-dependent kinase 2 (CDK2). Indirectly, it may impact RasGRP1 by affecting CDK-mediated signaling pathways, which intersect with Ras signaling, thereby influencing RasGRP1 activity and downstream cellular responses. | ||||||