RASGEF1B Activators
RASGEF1B activators, as detailed from the selection, comprise a class of chemicals that can indirectly modulate the function of RASGEF1B by targeting upstream or parallel signaling pathways, components, or intermediates. Central to the list are chemicals that influence the broader Ras pathway, given RASGEF1B's association with it. Epidermal Growth Factor (EGF), for instance, is a potent activator of the Ras signaling pathway. Its influence on the pathway activates RASGEF1B's function and its downstream effects.
Moreover, the Ras family's activity is deeply intertwined with the balance of GDP and GTP binding. Chemicals like GDP and GTPγS, which interact with Ras proteins, can pivot this balance, subsequently influencing RASGEF1B. Meanwhile, agents such as Forskolin and Isoproterenol, which impact cAMP levels, highlight the possible interplay between cAMP-mediated signaling and RASGEF1B. The significance of post-translational modifications, especially prenylation, in Ras function is underscored by the inclusion of Farnesyl pyrophosphate, Manumycin A, and Lovastatin. These compounds, by affecting the prenylation of Ras proteins, offers routes to modulate RASGEF1B indirectly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC which is known to influence Ras proteins and can affect RASGEF1B indirectly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels, which may have an indirect effect on RASGEF1B through cAMP-mediated signaling. | ||||||
Farnesyl pyrophosphate ammonium salt | 13058-04-3 | sc-200847 sc-200847A | 1 mg 5 mg | $478.00 $1977.00 | ||
Involved in the prenylation of Ras proteins; can impact the membrane localization and hence activity of RASGEF1B. | ||||||
Guanosine 5′-diphosphate disodium salt | 7415-69-2 | sc-211574 sc-211574A | 100 mg 500 mg | $206.00 $698.00 | ||
By binding to Ras proteins, GDP keeps them inactive. A balance between GTP and GDP binding modulates Ras activity and indirectly RASGEF1B. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium concentration, potentially affecting Ca²⁺-responsive elements in Ras pathways, including RASGEF1B. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Farnesyltransferase inhibitor; impacts Ras prenylation and can affect RASGEF1B indirectly. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Inhibits the synthesis of farnesyl pyrophosphate, affecting Ras prenylation and RASGEF1B activity. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Known to activate heterotrimeric G-proteins which can modulate Ras and RASGEF1B activity. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
A non-hydrolyzable GTP analog. By interacting with Ras, it can modulate its activity and indirectly affect RASGEF1B. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Adrenergic receptor agonist that can elevate cAMP levels and potentially modulate cAMP-responsive elements, including RASGEF1B. | ||||||