Molecular structure of Farnesyl pyrophosphate ammonium salt, CAS Number: 13058-04-3
Farnesyl pyrophosphate ammonium salt (CAS 13058-04-3)
Alternate Names:
FPP.3NH4
Application:
Farnesyl pyrophosphate ammonium salt is an isoprenoid farnesyl donor
CAS Number:
13058-04-3
Purity:
≥95%
Molecular Weight:
433.42
Molecular Formula:
C15H25O7P2•3NH4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Farnesyl pyrophosphate ammonium salt is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP may act to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: 2 mg/mL in 0.25M ammonium bicarbonate containing 70% ethanol.
Farnesyl pyrophosphate ammonium salt (CAS 13058-04-3) References
- Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme. | Reiss, Y., et al. 1992. J Biol Chem. 267: 6403-8. PMID: 1556143
- Steady-state kinetic mechanism of Ras farnesyl:protein transferase. | Pompliano, DL., et al. 1992. Biochemistry. 31: 3800-7. PMID: 1567835
- Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells. | Gauthaman, K., et al. 2009. Br J Pharmacol. 157: 962-73. PMID: 19438511
- Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells. | Qi, XF., et al. 2010. Toxicol Lett. 199: 277-87. PMID: 20883752
- Statins directly suppress cytokine production in murine intraepithelial lymphocytes. | Zhang, J., et al. 2013. Cytokine. 61: 540-5. PMID: 23290865
- The impact of statins on FGF-2-stimulated human umbilical vein endothelial cells. | Burgazli, KM., et al. 2014. Postgrad Med. 126: 118-28. PMID: 24393759
Activator of:
ABR, ABT1, arfaptin 1, ARHGAP25, ARHGEF17, ARL6IP6, ARL9, C8orf80, COQ2, COQ6, DIRAS2, E-Ras, EG667512, FTβ, GGTase-Iα, GGTase-Iβ, GGTase-IIβ, Gm1966, Gm600, GPR92, IDI1, IDI2, INDOL1, KIAA1024_AF529169, MVK, Olfr330, Olfr332, OR52A5, PIG-O, plexin-A2, plexin-B3, PTAR1, R-ras3, Rab 17, Rab 31, Rab 34, Rab 35, Rab 39, Rab 43, Rab 9A, RAB6IP1, Ral A, Ras2, RASEF, RASGEF1A, RASGEF1B, RCE1, RINL, SAMD8, StARD13, TBC1D22B, TBC1D2B, TM7SF2, and ZDHHC7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Farnesyl pyrophosphate ammonium salt, 1 mg | sc-200847 | 1 mg | $469.00 | |||
Farnesyl pyrophosphate ammonium salt, 5 mg | sc-200847A | 5 mg | $1938.00 |