Farnesyl pyrophosphate ammonium salt, in ethanol CAS: 13058-04-3
MF: C15H25O7P2•3NH4
MW: 433.42
An isoprenoid farnesyl donor.

Farnesyl pyrophosphate ammonium salt, in ethanol (CAS 13058-04-3)

Farnesyl pyrophosphate ammonium salt, in ethanol | CAS 13058-04-3 is rated 5.0 out of 5 by 1.
  • y_2020, m_3, d_29, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200847, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 130ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: FPP.3NH4
Application: An isoprenoid farnesyl donor
CAS Number: 13058-04-3
Purity: ≥98%
Molecular Weight: 433.42
Molecular Formula: C15H25O7P23NH4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Farnesyl pyrophosphate ammonium salt, in ethanol, is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase. It is also used for prenylation of several low molecular mass G proteins, including Ras. FPP has been shown to negate the inhibitory effects of cell growth for cells grown in high glucose conditions as well as to reverse the growth inhibitory effects of statins on variant human embryonic stem cells and cancer cells. FPP has also been detected in Alzheimer′s patients brains in elevated levels. Farnesyl pyrophosphate ammonium salt is an inhibitor of P2Y12. Concentration: 2 mg/mL in 0.25M ammonium bicarbonate containing 70% ethanol.


References

1. Pompliano, D.L., et al. 1992. Biochemistry. 31: 3800-3807. PMID: 1567835
2. Reiss, Y., et al. 1992. J. Biol. Chem. 267: 6403-6408. PMID: 1556143
3. Gauthaman, K., et al. 2009. Br. J. Pharmacol. 157: 962-973. PMID: 19438511
4. Ye, Y., et al. 2009. FEBS Lett. 583: 2997-3003. PMID: 19716825
5. Mather, A., et al. 2009. Int. J. Biochem. Cell Biol. 41: 561-569. PMID: 18692592
6. Hooff, G.P., et al. 2010. Biochim Biophys Acta.180: 896-905. PMID: 20382260

Usage :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Formulation :
0.25M ammonium bicarbonate containing 70% ethanol
Physical State :
Liquid
Solubility :
Soluble in water.
Storage :
Store at -20° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
71299715
MDL Number :
MFCD00189688
SMILES :
CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C.N.N.N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 120ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Burgazli Burgazli, KM. et al. (PubMed 24393759) investigated the effects of statins on proliferative and migrative behaviors of basic fibroblastic growth factor (FGF)-2 stimulated endothelial cells. Stimulation of statin-incubated cells with Farnesyl pyrophosphate ammonium salt, an isoprenoid farnesyl donor, had no additional effect on proliferation or migration. -SCBT Publication Review
Date published: 2015-06-06
  • y_2020, m_3, d_29, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200847, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 25ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.