Rae-1ε Activators
Forskolin, by increasing cAMP levels, indirectly augments Rae-1ε activity through the activation of PKA, which may phosphorylate Rae-1ε or other proteins involved in Rae-1ε-regulated processes. PMA mimics DAG and activates PKC, which can lead to the activation of Rae-1ε. Ionomycin and A23187, both calcium ionophores, raise intracellular calcium levels, potentially activating Rae-1ε through calcium-dependent signaling mechanisms. Sphingosine-1-phosphate engages with its receptors, possibly impacting Rae-1ε activity through Ras/Raf/ERK signaling pathways. LY294002 and U0126, as PI3K and MEK inhibitors respectively, might shift the balance of cellular signaling to favor Rae-1ε activation by altering the activity of pathways that regulate Rae-1ε's function or by compensatory activation of Rae-1ε in response to the inhibition of these pathways.
Epigallocatechin gallate, as a kinase inhibitor, could lift the suppression of Rae-1ε by inhibiting kinases that negatively regulate Rae-1ε, thereby enhancing its activity. SB203580, which inhibits p38 MAPK, could similarly lead to increased Rae-1ε function by alleviating the negative regulation exerted by p38 MAPK on Rae-1ε-associated pathways. Anisomycin, through its role in activating stress-activated protein kinases like JNK, may also contribute to the enhancement of Rae-1ε's role.. Lastly, BAY 11-7082's inhibition of NF-κB could result in the upregulation of alternative signaling pathways involving Rae-1ε, thereby promoting its activity. Collectively, these compounds exert their effects on precise cellular signaling routes to facilitate the enhancement of Rae-1ε's biological functions without directly modifying its expression levels or engaging it in a direct activation process.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which activates protein kinase A (PKA). PKA then phosphorylates target proteins, which could include Rae-1ε, thereby potentially enhancing its function within its specific cell signaling or immune response roles. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as a diacylglycerol (DAG) analog and potent activator of protein kinase C (PKC). By activating PKC, PMA could enhance Rae-1ε activity if PKC directly phosphorylates Rae-1ε or modulates its function through related signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. This elevation could indirectly enhance Rae-1ε's role in cellular processes that are regulated by calcium signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P engages with its receptors to activate downstream signaling cascades, such as those involving Ras/Raf/ERK, potentially influencing Rae-1ε activity if it is part of these signal transduction pathways or if its role is regulated by ERK-mediated events. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. By inhibiting MEK, PD 98059 could indirectly enhance Rae-1ε activity if Rae-1ε is modulated by ERK signaling or if its function is tied to MAPK pathway flux. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit various protein kinases. If Rae-1ε's activity is suppressed or regulated by any of these kinases, EGCG could potentially enhance Rae-1ε function by lifting this inhibition. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore similarly to Ionomycin, raising intracellular calcium levels. Increased calcium can activate various calcium-dependent proteins and pathways, possibly enhancing Rae-1ε function if it is calcium-regulated. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. By inhibiting p38 MAPK, it could allow for the enhancement of Rae-1ε activity, assuming Rae-1ε is involved in signaling pathways that are negatively regulated by p38 MAPK activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases like JNK. Activation of these pathways could potentially increase Rae-1ε activity if Rae-1ε is part of or regulated by these stress response pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation. By inhibiting NF-κB, it could enhance the activity of Rae-1ε if Rae-1ε is involved in alternative signaling pathways that become more active when NF-κB is inhibited. | ||||||