Rae-1δ Activators
Rae-1δ Activators are chemical compounds that influence the functional activity of Rae-1δ through a variety of cellular signaling mechanisms. Forskolin, by increasing cAMP levels, indirectly contributes to Rae-1δ's functional activity by stimulating PKA, which may phosphorylate components within Rae-1δ's signaling cascade, enhancing its role within the cell. PMA and Ionomycin, through PKC activation and calcium ionophoresis respectively, serve to modulate intracellular environments conducive to Rae-1δ's activity by altering kinase activities and calcium-dependent signaling, which are essential for Rae-1δ's function.
Rae-1δ activators belong to a distinctive chemical class characterized by their ability to modulate the expression of Rae-1δ, a cell surface glycoprotein that plays a crucial role in immune surveillance. The intricate mechanisms by which these activators operate involve the precise targeting of signaling pathways implicated in the regulation of Rae-1δ expression. Through well-defined methodologies, researchers have identified specific compounds within this class that demonstrate a pronounced efficacy in enhancing the transcriptional activity of Rae-1δ. These compounds, often synthesized through innovative synthetic routes, exhibit a remarkable capacity to engage with cellular receptors and transcription factors, ultimately leading to an upregulation of Rae-1δ at the molecular level. The exploration of Rae-1δ activators has leveraged cutting-edge techniques such as structure-activity relationship studies and computational modeling to elucidate the intricate interactions between these compounds and their cellular targets.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP may enhance Rae-1δ's role by activating PKA which could phosphorylate proteins within Rae-1δ's signaling network. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). Activation of PKC may enhance Rae-1δ's function by influencing downstream signaling pathways that Rae-1δ operates within. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, elevating intracellular calcium levels. This may activate calcium-dependent signaling pathways, potentially leading to the functional activation of Rae-1δ. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Inhibition of PI3K may disrupt competitive signaling pathways, skewing the activity towards pathways in which Rae-1δ is involved. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate affects lipid signaling pathways. Its action may contribute to enhancing Rae-1δ's functional activity by modulating lipid rafts and associated signaling pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. By selectively inhibiting kinases that negatively regulate Rae-1δ's pathway, it may indirectly enhance its activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein acts as a tyrosine kinase inhibitor. By blocking these kinases, Genistein may upregulate signaling processes in which Rae-1δ is involved. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis in cells. It may indirectly increase Rae-1δ's activity by enhancing calcium-dependent signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and may enhance Rae-1δ's activity by altering the signaling dynamics within the MAPK pathway, potentially favoring Rae-1δ's associated pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, it may impede competitive cell survival pathways, potentially leading to an increase in Rae-1δ's functional activity. | ||||||