Rabr Inhibitors
Rabr inhibitors encompass a range of chemical compounds that interact with various signaling pathways and cellular processes to ultimately reduce the functional activity of Rabr. Wortmannin and LY294002, both inhibitors of phosphoinositide 3-kinases, diminish AKT signaling, which may indirectly affect Rabr if it functions downstream in this pathway, especially in vesicle trafficking or cell survival. Rapamycin's inhibition of mTORC1 and Brefeldin A's blockade of ARF are particularly noteworthy, as they disrupt processes such as protein synthesis, autophagy, and vesicle formation from the Golgi, in which Rabr could play an integral role. Similarly, U0126 and PD98059 target the MEK/ERK pathway, while SB203580 and SP600125 interrupt p38 MAPK and JNK pathways, respectively, which could alter Rabr activity related to cellular differentiation, stress response, and apoptosis.
Further exploring the diversity of Rabr inhibitors, Gö6983's inhibition of protein kinase C isoforms, Genistein's interference with tyrosine kinase signaling, NSC23766's Rac1 inhibition, and ML141's blockade of Cdc42 underscore the complex nature of Rabr regulation through variousaspects of cellular signaling and cytoskeletal dynamics. The inhibition of PKC by Gö6983, for instance, could lead to a decrease in Rabr activity by affecting signal transduction pathways that rely on PKC for vesicle trafficking. On the other hand, Genistein, by inhibiting tyrosine kinases, may indirectly influence Rabr's role in vesicle movement or cytoskeletal rearrangements. NSC23766 and ML141 target small GTPases, Rac1, and Cdc42, respectively, which are critical for actin cytoskeleton organization and vesicle trafficking. The inhibition of these GTPases might disrupt Rabr's potential involvement in membrane dynamics and signaling pathways that depend on the proper organization of the actin cytoskeleton, further contributing to the inhibition of Rabr's function in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, it prevents the activation of AKT, leading to a reduction in cell survival signals that could indirectly decrease Rabr activity if Rabr is downstream of PI3K/AKT signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor that prevents AKT phosphorylation and activation. It results in an inhibition of the PI3K/AKT/mTOR pathway, which plays a role in vesicle trafficking, where Rabr could be implicated. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream regulators of the ERK/MAPK pathway. By inhibiting this pathway, U0126 could indirectly affect Rabr function related to cellular growth and differentiation signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically inhibits mTORC1, which is involved in protein synthesis and autophagy. Inhibition of mTORC1 can disrupt processes that may involve Rabr, such as vesicle formation and trafficking. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a protein involved in response to stress and inflammation. Inhibition of p38 MAPK could influence cellular processes that involve Rabr, such as vesicle-mediated transport or cytokine production. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which blocks the activation of MAPK/ERK. This inhibition could affect Rabr activity if Rabr is linked to signal transduction pathways regulated by ERK. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which influences cellular processes including apoptosis and inflammation. By inhibiting JNK, SP600125 could affect Rabr activity in pathways associated with stress responses. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), which is critical for vesicle formation from the Golgi. Since Rabr is potentially involved in vesicular trafficking, Brefeldin A may indirectly impact Rabr function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö6983 is a broad-spectrum inhibitor of protein kinase C (PKC) isoforms. PKC is implicated in various cellular processes, and inhibition of PKC can indirectly affect Rabr function in signal transduction or vesicle trafficking. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may indirectly affect Rabr function by inhibiting signaling pathways where tyrosine kinase activity is required for vesicle movement or cytoskeletal rearrangements. | ||||||