rabphilin-11 Activators
Rabphilin-3A activators primarily consist of compounds that indirectly influence the activity of Rabphilin-3A through various cellular and molecular mechanisms. These chemicals target key aspects of cellular function, such as GTPase activity, vesicle trafficking, cytoskeletal dynamics, and phosphorylation states, which are integral to the regulation and function of Rabphilin-3A.
GTPγS, for instance, functions by stabilizing the GTP-bound active form of Rab proteins, thereby enhancing the interaction and functional activation of Rabphilin-3A. Other compounds, like Brefeldin A and Forskolin, exert their effects on general vesicle trafficking and intracellular signaling pathways, respectively, which could indirectly modulate Rabphilin-3A activity. Brefeldin A disrupts Golgi dynamics, while Forskolin elevates cAMP levels, both of which are crucial in synaptic vesicle dynamics where Rabphilin-3A plays a role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
A non-hydrolyzable analog of GTP, GTPγS can indirectly activate Rabphilin-3A by stabilizing Rab3 in its active GTP-bound state, promoting Rabphilin-3A binding and function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This compound disrupts the Golgi structure and function, potentially affecting vesicle trafficking pathways in which Rabphilin-3A is involved. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP may indirectly influence Rabphilin-3A activity by modulating synaptic vesicle dynamics. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins involved in vesicle trafficking, potentially influencing Rabphilin-3A's function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
As a potent inhibitor of protein phosphatases PP1 and PP2A, okadaic acid may indirectly affect Rabphilin-3A by altering phosphorylation states of proteins in its pathway. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules, impacting cellular transport mechanisms that could indirectly influence Rabphilin-3A activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
This compound binds to actin monomers, preventing polymerization and affecting cytoskeletal dynamics, potentially impacting Rabphilin-3A's role in vesicle trafficking. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $62.00 | 8 | ||
Ammonium chloride can alter intracellular pH, which might influence Rabphilin-3A's activity in vesicle trafficking and neurotransmitter release. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
This ionophore disrupts intracellular ion homeostasis, potentially affecting Rabphilin-3A's function in vesicle dynamics. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A dynamin inhibitor, Dynasore can impact vesicle scission and endocytosis, processes potentially linked to Rabphilin-3A activity. | ||||||