rabphilin-11 Inhibitors
Rabphilin-11 inhibitors are compounds primarily characterized by their ability to interfere with the functional properties and signaling pathways associated with the rabphilin proteins indirectly. The specificity to rabphilin-11 remains largely undefined due to limited available data, but the broader family's involvement in the Rab GTPase-mediated processes provides a foundation.
These inhibitors can target key components in the Rho GTPase signaling, such as ROCK (Rho-associated coiled-coil kinases) using molecules like Y-27632 or H1152P, and Rac1 GTPases with compounds like NSC23766 or EHop-016. Furthermore, rabphilin-related pathways also encompass other essential signaling cascades, such as the PI3K/AKT pathway, targeted by LY294002 or Ipatasertib, and the MAPK pathway, affected by PD0325901. Such chemicals, by modulating the activities of these pathways, can thus regulate the function or downstream effects of rabphilin-11 and related proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor. Rabphilins can be involved in processes regulated by Rho-associated coiled-coil kinases (ROCK), and inhibiting ROCK can affect their function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor. PI3K pathway might be upstream to several Rab GTPases and proteins they interact with. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor. Similar to LY294002 in its inhibition mechanism. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
A Cdc42 inhibitor. Given that Cdc42 is a GTPase, it's plausible that rabphilins have functional interactions in pathways involving Cdc42. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
Another ROCK inhibitor. Similar rationale as Y-27632. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
An inhibitor of Rac1-GEF interaction. Rabphilins can be indirectly influenced by modulating Rac1 activity. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
PAK1 inhibitor. P21-activated kinases (PAKs) can be downstream effectors of Rac/Cdc42 GTPases. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
Cdc42-specific inhibitor, affecting pathways involving this GTPase. | ||||||
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone | sc-501166 | 5 mg | $540.00 | |||
AKT inhibitor, a downstream element of PI3K pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, can potentially modulate pathways involving rabphilin proteins. | ||||||