QTRT1 Inhibitors
QTRT1 Inhibitors are a group of compounds that indirectly affect the functional activity of QTRT1 by manipulating the availability of nucleotide substrates or the balance of nucleotide pools within cells. These inhibitors act on various enzymes and pathways involved in nucleotide synthesis and metabolism, which are critical for the proper functioning of QTRT1 in tRNA modification. Allopurinol, for instance, inhibits xanthine oxidase, a key enzyme in purine metabolism, leading to lower levels of uric acid and potentially altering the pool of free purines. This can indirectly reduce the substrates available for QTRT1 activity. Similarly, 6-Thioguanine and 6-Mercaptopurine, as purine antimetabolites, directly interfere with the synthesis and function of purine nucleotides, creating an environment where the balance of nucleotides is disrupted, which could limit the capacity of QTRT1 to carry out tRNA modification.
Compounds like Methotrexate and Azathioprine, while targeting different primary enzymes, also impact purine synthesis and therefore could indirectly influence QTRT1 activity. Antiviral nucleoside analogs, such as Acyclovir and Ganciclovir, are designed to inhibit viral DNA polymerases, but the alterations they cause in cellular nucleotide levels can also have an unintentional impact on cellular processes including QTRT1's role in tRNA modification. Ribavirin and Tiazofurin, which inhibit inosine monophosphate dehydrogenase, lead to reduced GTP pools, potentially impeding QTRT1 function, given that GTP is a necessary substratefor tRNA modification. Mycophenolic acid operates in a similar fashion by diminishing guanine nucleotide synthesis, which is essential for the enzymatic activity of QTRT1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
An inhibitor of xanthine oxidase, affecting purine metabolism. By reducing the production of uric acid, allopurinol can indirectly inhibit QTRT1 by decreasing the pool of free purines, which could be required for optimal tRNA modification. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
A guanine analog that acts as a purine antimetabolite, interfering with nucleotide synthesis and function. It can disrupt the purine nucleotide pool balance, potentially leading to an indirect inhibition of QTRT1's tRNA modification activity. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
Another purine antimetabolite that inhibits purine nucleotide synthesis and interconversion. This inhibition can lead to a reduced availability of purine nucleotides, indirectly affecting QTRT1 function. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
While primarily known as a dihydrofolate reductase inhibitor, methotrexate also affects purine synthesis. The resultant decrease in purine availability can indirectly inhibit QTRT1. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $203.00 $176.00 $349.00 $505.00 $704.00 | 1 | |
A prodrug for 6-mercaptopurine, it interferes with purine nucleotide synthesis and metabolism, potentially reducing the availability of substrates for QTRT1 function. | ||||||
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $150.00 $940.00 | 2 | |
A guanosine analog that targets viral DNA polymerase but also could influence cellular kinases, potentially altering nucleotide pools and indirectly inhibiting QTRT1. | ||||||
Ganciclovir | 82410-32-0 | sc-203963 sc-203963A | 50 mg 250 mg | $233.00 $421.00 | 1 | |
Similar to acyclovir, this guanosine analog can inhibit viral DNA polymerases and potentially impact cellular guanine nucleotide levels, indirectly inhibiting QTRT1. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
A guanosine analog that reduces GTP pools by inhibiting inosine monophosphate dehydrogenase, which could indirectly inhibit QTRT1 by limiting the available GTP for tRNA modification. | ||||||
Tiazofurin | 60084-10-8 | sc-475805 | 5 mg | $449.00 | ||
An inhibitor of inosine monophosphate dehydrogenase, it can deplete GTP pools and indirectly inhibit QTRT1 function in tRNA modification. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
By inhibiting inosine monophosphate dehydrogenase and decreasing guanine nucleotide synthesis, this compound can indirectly inhibit QTRT1. | ||||||