PYGL Activators
PYGL, or glycogen phosphorylase, is a crucial enzyme in cellular energy metabolism, orchestrating glycogen breakdown to release glucose. While direct activators of PYGL are not well-defined, several chemicals can indirectly modulate its activity through the AMP-activated protein kinase (AMPK) pathway. A769662, Berberine, AICAR, Metformin, Resveratrol, Salicylate, ZMP, Oltipraz, Compound C, 2-Deoxyglucose, and Dorsomorphin represent a cohort of compounds that, through diverse mechanisms, impact AMPK activation, thereby influencing PYGL.
These chemicals act on the AMPK pathway, directly or indirectly activating this energy-sensing kinase. A769662, for instance, directly phosphorylates and activates AMPK, initiating a cascade of events. Berberine and AICAR mimic adenosine, activating AMPK, while Metformin alters cellular energy metabolism. Resveratrol, Salicylate, and Oltipraz influence AMPK activation, emphasizing the interconnectedness of cellular energy pathways. ZMP, a purine biosynthesis intermediate, mimics AMP, impacting AMPK and, consequently, PYGL. Notably, AMPK inhibitor Compound C and glycolysis inhibitor 2-Deoxyglucose highlight the reciprocal relationship between AMPK activation and PYGL regulation. Dorsomorphin, another AMPK inhibitor, further underscores the complexity of this interplay. In summary, these chemicals collectively exemplify a group of PYGL activators, indirectly modulating cellular energy homeostasis through the AMPK pathway. Understanding their specific biochemical and cellular influences provides insights into the intricate regulation of PYGL and offers potential avenues for further exploration in the realm of cellular energy metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A potent AMP-activated protein kinase (AMPK) activator that directly phosphorylates and activates AMPK. This activation leads to downstream effects on cellular energy homeostasis, potentially influencing PYGL through AMPK-mediated pathways. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Acts as an activator of AMPK, affecting cellular energy balance. By activating AMPK, berberine can indirectly modulate PYGL through the AMPK signaling cascade, potentially influencing glycogenolysis. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
An adenosine analog that activates AMPK, impacting cellular energy sensing and homeostasis. Through AMPK activation, AICAR can indirectly influence PYGL by modulating downstream pathways related to energy metabolism. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Functions as an AMPK activator, impacting cellular energy metabolism. By activating AMPK, metformin can indirectly influence PYGL, potentially modulating glycogenolysis and other processes related to cellular energy balance. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates AMPK, influencing cellular energy status. Through AMPK activation, resveratrol can indirectly modulate PYGL, potentially affecting glycogenolysis and contributing to the regulation of cellular energy homeostasis. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Acts as an activator of AMPK, impacting cellular energy pathways. Through AMPK activation, salicylate can indirectly influence PYGL, potentially modulating glycogenolysis and contributing to the regulation of cellular energy homeostasis. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Activates AMPK, impacting cellular energy sensing and homeostasis. By activating AMPK, oltipraz can indirectly influence PYGL, potentially modulating glycogenolysis and contributing to the regulation of cellular energy balance. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
An AMPK inhibitor that indirectly influences PYGL. By inhibiting AMPK, BML-275 can potentially modulate glycogenolysis and other processes related to cellular energy balance, highlighting the reciprocal nature of AMPK activation and PYGL regulation. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glucose analog that competitively inhibits glycolysis. By affecting cellular glucose metabolism, 2-deoxyglucose can indirectly influence PYGL, potentially impacting glycogenolysis and contributing to alterations in cellular energy homeostasis. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
An AMPK inhibitor with potential indirect effects on PYGL. By inhibiting AMPK, dorsomorphin can potentially modulate glycogenolysis and other processes related to cellular energy balance, highlighting the reciprocal nature of AMPK activation and PYGL regulation. | ||||||