PSMD12 activators comprise a diverse array of chemical compounds that indirectly elevate the functional activity of PSMD12 through distinct cellular mechanisms. For instance, Forskolin, by increasing cAMP levels, can activate PKA, which may phosphorylate substrates that enhance PSMD12 function within the ubiquitin-proteasome pathway. Autophagy inducers like Spermidine indirectly necessitate a greater PSMD12 role by increasing the cellular demand for protein degradation, thus highlighting the interplay between autophagy and the proteasome system.
Furthermore, compounds such as AICAR and Metformin activate AMPK, a master regulator of energy homeostasis, which could enhance PSMD12 activity in response to energetic stress. Resveratrol, through SIRT1 activation, could promote PSMD12 activity indirectly by improving the deacetylation and function of proteasome components. Rapamycin, an mTOR inhibitor, might augment PSMD12 activity by enhancing autophagy, thereby indirectly increasing proteasomal degradation demand. Lithium Chloride, by inhibitingGSK-3, may stabilize and improve PSMD12's role in the ubiquitin-proteasome pathway. Salubrinal, by blocking eIF2α dephosphorylation, could indirectly necessitate increased PSMD12 activity due to an elevated presence of misfolded proteins requiring degradation. Finally, Curcumin, with its ability to modulate multiple signaling pathways including NF-κB, may enhance PSMD12 activity by influencing the regulatory mechanisms governing proteasome function.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA. PKA phosphorylation can enhance the activity of PSMD12 in the ubiquitin-proteasome pathway. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is known to induce autophagy and may enhance PSMD12 activity indirectly by modulating protein degradation pathways that interface with the proteasome system. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can phosphorylate certain substrates leading to the enhancement of PSMD12 as part of the cellular energy homeostasis response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, potentially enhancing PSMD12 activity indirectly through deacetylation of proteasome components and improving proteasome function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, potentially enhancing autophagy and indirectly increasing demand for PSMD12's proteolytic activity in protein quality control. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3, which may lead to the stabilization and enhancement of PSMD12 function in the ubiquitin-proteasome pathway. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is an eIF2α phosphatase inhibitor, which may enhance PSMD12 activity indirectly by increasing the need for proteasomal degradation of misfolded proteins. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, which can lead to enhanced PSMD12 activity as part of the cellular stress response to restore energy balance. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways, potentially enhancing PSMD12 activity by affecting NF-κB signaling and proteasome function. |