PSMD1 Activators
PSMD1 activators refers to a specific class of chemical compounds known for their capacity to modulate the activity of the PSMD1 protein. PSMD1, also recognized as 26S proteasome non-ATPase regulatory subunit 1, is an essential component of the 26S proteasome complex, a key cellular machinery responsible for targeted protein degradation. Within this intricate proteolytic system, PSMD1 acts as a non-ATPase regulatory subunit, playing a crucial role in the recognition and unfolding of ubiquitin-tagged proteins destined for degradation.
Chemical entities classified as PSMD1 activators are believed to interact with the PSMD1 protein, influencing its function and consequently affecting the overall activity of the 26S proteasome complex. This modulation of PSMD1 activity may result in alterations to the ubiquitin-proteasome system, impacting the degradation of specific proteins within the cell. The mechanistic details of how these activators precisely engage with PSMD1 and the downstream consequences of such interactions remain areas of ongoing research. Understanding the molecular intricacies of PSMD1 activation could potentially unveil novel insights into cellular processes regulated by the proteasome and may have implications for various biological phenomena, although the specific nature of these implications remains a subject for further scientific investigation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that hampers the degradation of proteins in cells. By inhibiting the proteasome activity, it enhances the functional activity of PSMD1, which is a component of the 26S proteasome. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor. It directly interacts with the 26S proteasome and inhibits its activity, which indirectly enhances the functional activity of PSMD1. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a potent, selective, irreversible and cell-permeable proteasome inhibitor. It enhances the activity of PSMD1 by inhibiting the proteasome activity. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. It inhibits the proteasome activity, thereby increasing the functional activity of PSMD1. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-range DUB inhibitor. It enhances the functional activity of PSMD1 by inhibiting deubiquitinating enzymes (DUBs) that counteract the proteasome's function. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $243.00 | ||
PQQ is a redox cofactor that can enhance the assembly and activity of 20S proteasome, which can indirectly influence the 26S proteasome and PSMD1. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is an antioxidant that can enhance the proteasome activity under oxidative stress, indirectly affecting the activity of PSMD1. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine is a natural product that can enhance the proteasome activity under stress conditions, indirectly affecting the activity of PSMD1. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a natural product that can inhibit the proteasome activity under stress conditions, indirectly enhancing the activity of PSMD1. | ||||||