PSD3 Activators
Pleckstrin and Sec7 domain-containing protein 3 (PSD3) is a member of the PSD family of proteins characterized by the presence of Sec7 and pleckstrin homology (PH) domains. These domains are indicative of roles in cellular signaling and membrane trafficking. The Sec7 domain is known to possess guanine nucleotide exchange factor (GEF) activity, which is essential for the activation of ADP-ribosylation factors (ARFs), a family of small GTPases involved in vesicle formation and trafficking.PSD3 is expressed in various tissues, and its cellular function is linked to the regulation of membrane dynamics and cytoskeletal organization. Through its GEF activity, PSD3 can activate ARF proteins, thereby influencing the remodeling of membranes and contributing to processes such as endocytosis, secretion, and the maintenance of organelle structure.
The pleckstrin homology domain of PSD3 allows it to interact with phosphoinositides, which are important lipid signaling molecules in the plasma membrane and other intracellular membranes. This interaction may target PSD3 to specific membrane sites where it can exert its effects on membrane trafficking and cytoskeletal organization.While the exact physiological roles of PSD3 remain to be fully characterized, research has suggested it may play a part in cell division and cytokinesis, given its potential to influence the cytoskeleton. Furthermore, PSD3 has been implicated in neurological development and function, potentially through its interactions with other proteins in neurons.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi structure and function, potentially affecting PSD3 activity by impacting intracellular trafficking processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
As a PI3K inhibitor, Wortmannin may indirectly influence PSD3 by modulating PI3K/Akt signaling pathways, which intersect with membrane trafficking. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, could indirectly affect PSD3 activity by altering signaling pathways that involve tyrosine phosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels and could influence PSD3 indirectly if it's involved in cAMP-dependent signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can affect multiple signaling pathways and might indirectly influence PSD3 through its anti-inflammatory and antioxidant properties. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, can alter various cellular pathways and might indirectly affect PSD3 activity if it's involved in mTOR-regulated processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a PI3K inhibitor, LY294002 could indirectly influence PSD3 activity by impacting PI3K/Akt signaling pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC, known for its antioxidant properties, might indirectly affect PSD3 activity by modulating redox signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects gene expression and oxidative stress response, potentially impacting PSD3 activity if linked to these mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, an MEK inhibitor, might indirectly influence PSD3 activity by affecting the ERK/MAPK signaling pathway. | ||||||