PRR22 Activators
PRR22 Activators encompass a diverse array of chemical compounds that indirectly enhance the protein's functional activity through modulation of various signaling pathways. Forskolin and IBMX both target the cAMP signaling axis, with Forskolin stimulating cAMP synthesis and IBMX inhibiting its degradation, thereby bolstering PKA activity which could phosphorylate and enhance the function of PRR22. Similarly, PMA serves as an activator of PKC, another kinase that may phosphorylate PRR22, thereby augmenting its activity. Ionomycin and A23187, by elevating intracellular calcium levels, activate calcium-dependent kinases that could facilitate the activation of PRR22. Additionally, Epigallocatechin gallate's broad-spectrum kinase inhibition might decrease competitive signaling, indirectly enhancing kinases that activate PRR22.
The activity of PRR22 is further influenced by compounds that affect various other signaling molecules and pathways. Sildenafil and Zaprinast, as inhibitors of PDE5 and other phosphodiesterases, respectively, elevate cGMP levels to potentially enhance PKG activity, which could then activate PRR22. L-Arginine contributes to this process by serving as a precursor for nitric oxide synthesis, which in turn can activate guanylate cyclase and increase cGMP levels, offering another route for PRR22 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly elevates intracellular cAMP levels, which can lead to activation of PKA. PKA is known to phosphorylate various proteins, which could include PRR22, thereby enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX, a nonspecific inhibitor of phosphodiesterases, prevents cAMP degradation, thus potentially increasing the activity of PKA. This, in turn, could lead to enhanced phosphorylation and activity of PRR22. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
As a broad-spectrum kinase inhibitor, Epigallocatechin gallate could reduce competitive kinase activity, potentially allowing for the enhanced activity of kinases that specifically activate PRR22. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which could activate calcium-dependent kinases that enhance PRR22 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which could lead to the phosphorylation of substrates that include PRR22, thus increasing its activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin acts as a JNK activator; JNK pathway activation could lead to phosphorylation of target proteins, including potentially PRR22, thereby enhancing its activity. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase, leading to increased production of nitric oxide, which could activate guanylate cyclase and increase cGMP levels, indirectly enhancing PRR22 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase inhibitor, which could lead to changes in the actin cytoskeleton, potentially influencing signaling pathways that activate PRR22. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which could shift the balance of intracellular signaling, potentially upregulating pathways that activate PRR22. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium, potentially activating calcium-dependent kinases that may enhance PRR22 activity. | ||||||