PRPF4 Activators
PRPF4 Activators are compounds that indirectly influence the activation of PRPF4 by targeting the biochemical pathways or cellular processes PRPF4 is involved in. Notably, these chemicals operate in various signaling networks, such as histone modification (Trichostatin A, 5-Azacytidine, Genistein), spliceosome assembly and function (Spliceostatin A, Pladienolide B), kinase activation pathways (Anisomycin, A-83-01, LY294002, SU11274), and protein stabilization (Geldanamycin). By affecting these individual elements, they can create a biochemical environment conducive to PRPF4 activation.
Importantly, the specificity and mechanisms through which these chemicals exert their effect can be vastly different. For example, spliceosome-targeting agents like Spliceostatin A and Pladienolide B directly impact the SF3b complex, leading to a cascade of cellular responses that could promote PRPF4 activation. In contrast, compounds like Resveratrol and Anisomycin target more broadly acting pathways like SIRT1 activation and JNK activation, respectively. Nonetheless, by acting on these pathways, they create conditions that can favor PRPF4 activity, such as altering chromatin accessibility for better pre-mRNA splicing or promoting phosphorylation of related splicing factors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It promotes acetylation of histones, facilitating chromatin remodeling, and indirectly enhancing pre-mRNA splicing, potentially resulting in increased PRPF4 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that induces global DNA hypomethylation, potentially activating gene expression pathways related to PRPF4. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Spliceostatin A binds to the SF3b complex, blocking spliceosome assembly. The inhibition can lead to compensatory mechanisms that might upregulate PRPF4. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK pathway activator. The activation of the JNK pathway enhances the phosphorylation of splicing factors, which could indirectly increase PRPF4 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate SIRT1, which in turn has been shown to be involved in RNA splicing regulation. SIRT1 activation could lead to the indirect enhancement of PRPF4 functionality in the spliceosome complex. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can also modulate chromatin structure by affecting histone acetylation. The altered chromatin state can impact PRPF4 indirectly by modulating pre-mRNA splicing. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A-83-01 is a TGF-beta receptor inhibitor. By inhibiting this receptor, Smad-dependent signaling can be suppressed, thereby potentially affecting alternative splicing events and influencing PRPF4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K inhibition leads to a decrease in AKT signaling, which is linked to the regulation of RNA splicing, thereby potentially modulating PRPF4 activity. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity, which has an indirect role in the transport of splicing factors within the nucleus. This could lead to an increased localization of PRPF4 to spliceosomes. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin inhibits Hsp90, which is known to interact with several RNA splicing factors. By inhibiting Hsp90, the stability of splicing factors might be affected, which could indirectly influence PRPF4. | ||||||