Protogenin Inhibitors
Protogenin inhibitors belong to a class of chemical agents that are characterized by their ability to modulate the activity of the biological target known as protogenin. Protogenin is a protein that plays a crucial role in various cellular processes, including cell signaling pathways, cellular differentiation, and development. The inhibitors are designed to interact with this protein in a way that alters its function, which can have a range of downstream effects on cellular activity. The exact mechanism of action of these inhibitors can vary depending on their chemical structure and the specific site on the protogenin protein they are designed to target.
The development of protogenin inhibitors requires a deep understanding of the structure and function of the protogenin protein itself. This includes knowledge of the protein's active sites, conformational states, and its interactions with other cellular components. The chemical structures of protogenin inhibitors are often complex, reflecting the need to specifically engage with the protogenin protein with high affinity and selectivity. Researchers in the field of chemical biology and medicinal chemistry spend considerable effort in the design, synthesis, and optimization of these compounds. Advanced techniques such as high-throughput screening, computational modeling, and structure-activity relationship (SAR) studies are commonly employed to identify and enhance potential inhibitors. The ultimate goal of these efforts is to produce molecules that can effectively influence the function of the protogenin protein in a predictable and controlled manner.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a CDK4/6 inhibitor that indirectly decreases Protogenin activity by inhibiting cell cycle progression. Protogenin is associated with cellular growth, and its activity is modulated during the cell cycle. By arresting the cell cycle, Palbociclib can downregulate Protogenin activity as part of the altered cellular state. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor that indirectly inhibits Protogenin by disrupting the PI3K/AKT pathway, which is crucial for multiple cellular processes including those that regulate cell survival and growth, potentially affecting Protogenin functionality. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can impede cell growth and proliferation pathways, indirectly affecting Protogenin activity, as Protogenin is thought to be involved in cell proliferation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can interfere with the MAPK/ERK pathway, leading to reduced activity of downstream proteins such as Protogenin that are implicated in cell growth and differentiation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can disrupt inflammatory response pathways. As Protogenin may interact with signaling pathways involved in inflammation, inhibiting p38 MAPK could result in decreased Protogenin activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can attenuate AKT signaling, thereby indirectly inhibiting Protogenin activity by disrupting growth and survival pathways where Protogenin may have a role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that can interfere with the JNK signaling pathway, which may modulate Protogenin activity indirectly by affecting cellular stress responses and apoptosis where Protogenin might be involved. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that can hinder cytoskeleton organization and cell motility, processes in which Protogenin could potentially be involved. Inhibiting ROCK could therefore lead to reduced Protogenin activity by affecting these cellular processes. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an AKT inhibitor that can diminish Protogenin activity by directly disrupting the AKT signaling pathway, which is involved in cell survival and growth where Protogenin may play a role. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor similar to U0126, which can suppress the MAPK/ERK pathway, resulting in a downstream decrease in Protogenin activity related to cell division and differentiation. | ||||||