PRODH2 Activators
PRODH2 Activators are chemicals that indirectly stimulate PRODH2, an enzyme involved in proline metabolism, by influencing upstream cellular processes. Two primary pathways are implicated: the calcium/calmodulin-dependent protein kinase II (CaMKII)-STAT3 pathway and the cAMP-dependent protein kinase (PKA)-CREB pathway.
Chemicals like NMDA, Gabapentin, Verapamil, Nifedipine, A23187, Thapsigargin, Amlodipine, and Diltiazem elevate intracellular calcium levels, triggering the CaMKII-STAT3 pathway. Activated CaMKII phosphorylates STAT3, leading to increased PRODH2 expression. In the PKA-CREB pathway, chemicals like Pentoxifylline and Forskolin raise intracellular cAMP levels. Elevated cAMP activates PKA, which phosphorylates CREB, leading to increased PRODH2 transcription. The diverse structures and properties of these chemicals reflect their various methods of modulating calcium and cAMP levels, which in turn influence PRODH2 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $107.00 $362.00 | 2 | |
NMDA is an agonist of the NMDA receptor, which can increase intracellular calcium levels. The influx of calcium can activate the calcium/calmodulin-dependent protein kinase II (CaMKII) pathway. CaMKII phosphorylates Ser727 on STAT3, leading to an increase in PRODH2 expression. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
Gabapentin, a GABA analogue, increases the intracellular calcium concentration by acting on voltage-gated calcium channels. The rise in calcium levels can activate the CaMKII-STAT3 pathway, indirectly leading to increased PRODH2 expression. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
EGTA is a calcium chelator that can reduce intracellular calcium levels. Lowering calcium levels can decrease CaMKII activity, indirectly reducing PRODH2 expression. This implies that an increase in calcium can promote PRODH2 expression. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can increase intracellular calcium levels under certain conditions. Increased calcium can activate the CaMKII-STAT3 pathway, leading to upregulation of PRODH2. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker that can increase intracellular calcium levels under certain conditions. Increased calcium can activate the CaMKII-STAT3 pathway, leading to upregulation of PRODH2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium levels. Increased calcium can activate the CaMKII-STAT3 pathway, leading to upregulation of PRODH2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarco-/endoplasmic reticulum Ca2+ ATPase (SERCA), causing an increase in intracellular calcium levels. Increased calcium can activate the CaMKII-STAT3 pathway, leading to upregulation of PRODH2. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine is a calcium channel blocker that can increase intracellular calcium levels under certain conditions. Increased calcium can activate the CaMKII-STAT3 pathway, leading to upregulation of PRODH2. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a specific inhibitor of CaMKII. By inhibiting CaMKII, KN-93 reduces the phosphorylation of STAT3, indirectly reducing PRODH2 expression. This implies that activation of CaMKII can promote PRODH2 expression. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is a calcium channel blocker that can increase intracellular calcium levels under certain conditions. Increased calcium can activate the CaMKII-STAT3 pathway, leading to upregulation of PRODH2. | ||||||