PRKX Activators
Protein Kinase X-Linked (PRKX) is a serine/threonine kinase with an essential role in multiple cellular and physiological processes. As a member of the protein kinase family, PRKX shares homology with the cAMP-dependent, cGMP-dependent, and protein kinase C (PKC) families, which are pivotal in the regulation of cellular signaling pathways. PRKX has garnered attention for its involvement in the Wnt signaling cascade, a crucial pathway for cell proliferation and differentiation, as well as its importance in developmental biology, particularly in the nervous system. Furthermore, PRKX is linked to the maintenance of fluid and electrolyte homeostasis, positioning it as a significant contributor to cellular function and health. The regulation of PRKX expression is complex, influenced by a variety of intracellular and extracellular factors that can adjust its activity in response to specific biological needs.
Several specific chemical compounds have been identified as potential activators of PRKX expression, each acting through distinct biochemical mechanisms. Compounds like Forskolin and Dibutyryl-cAMP (db-cAMP) are known to elevate intracellular levels of cyclic AMP (cAMP), a secondary messenger that activates PKA and can enhance the transcription of target genes including PRKX. Other activators such as Phorbol 12-Myristate 13-Acetate (PMA) function by stimulating protein kinase C, which plays a role in the activation of signaling pathways leading to gene expression. Additionally, molecules like Retinoic Acid and Vitamin D3 operate through nuclear receptors that upon ligand binding, directly interact with DNA to drive gene transcription, potentially increasing the expression of PRKX. Intracellular calcium modulators like Ionomycin and Thapsigargin also serve as activators by altering calcium signaling, which triggers a cascade of events culminating in the upregulation of genes sensitive to calcium levels. These compounds exemplify the diverse array of molecules that can induce the expression of PRKX, reflecting the intricate network of cellular signaling that governs the expression of this protein kinase.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to a rise in intracellular cAMP levels, which can subsequently upregulate PRKX expression via cAMP-dependent protein kinase A (PKA) activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid interacts with retinoic acid receptors (RARs) that bind to DNA response elements to initiate transcription, potentially increasing PRKX gene transcription in responsive cells. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a synthetic cAMP analog, diffuses into cells and serves as a potent activator of PKA, which may stimulate the transcriptional activity of genes including PRKX. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone, by blocking aldosterone receptors, may prompt a compensatory response in cells that includes the upregulation of PRKX as part of homeostatic balance restoration. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can enhance glycogen synthase kinase-3 (GSK-3) inhibition, a key component of the Wnt/β-catenin pathway, potentially leading to the increased expression of PRKX. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, by inhibiting histone deacetylases, can cause histone hyperacetylation, promoting a more open chromatin structure that may enhance PRKX gene transcription. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can initiate a signaling cascade leading to the transcriptional activation of various genes, including the PRKX gene. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a synthetic sympathomimetic, can bind to beta-adrenergic receptors and stimulate adenylate cyclase, thereby raising cAMP levels which might stimulate PRKX expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, by increasing intracellular calcium concentrations, can activate calcium-dependent protein kinases and transcription factors that may upregulate PRKX transcription. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium storage by inhibiting the SERCA pump, leading to a cascade that can stimulate the expression of calcium-responsive genes like PRKX. | ||||||