PRIM1 Inhibitors
PRIM1 inhibitors belong to a specific category of chemical compounds designed to target and inhibit the activity of the PRIM1 enzyme, which stands for DNA Primase Subunit 1. PRIM1 is an essential component of the DNA replication machinery, playing a central role in initiating DNA replication by synthesizing short RNA primers that serve as templates for the synthesis of new DNA strands. DNA replication is a fundamental process in cell division, ensuring the faithful duplication of the genetic material during cell proliferation. The PRIM1 enzyme is vital for ensuring the accuracy and efficiency of DNA replication, making it a critical player in maintaining genomic stability. Inhibitors of PRIM1 are primarily developed for research purposes, serving as valuable tools for scientists and researchers to investigate the molecular mechanisms and functions associated with this enzyme in the context of DNA replication and cellular biology.
PRIM1 inhibitors are typically composed of small molecules or chemical compounds specifically designed to interact with the PRIM1 enzyme, disrupting its normal function in DNA replication. By inhibiting PRIM1, these compounds can potentially interfere with the initiation of DNA synthesis, leading to alterations in DNA replication and cell cycle progression. Researchers use PRIM1 inhibitors in laboratory settings to manipulate the activity of this enzyme and study its roles in various aspects of DNA replication and genome stability. These inhibitors provide valuable insights into the molecular mechanisms by which PRIM1 facilitates the replication of genetic material and contribute to a deeper understanding of its significance in the context of cellular biology and DNA replication processes. While PRIM1 inhibitors may have broader implications, their primary purpose is to assist scientists in deciphering the intricacies of PRIM1-mediated DNA replication and its impact on genomic integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
A tetracyclic diterpene that selectively inhibits DNA polymerases, potentially reducing the demand for PRIM1 function. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog that can be incorporated into DNA, potentially disrupting the action of DNA primases indirectly. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $58.00 $204.00 | 15 | |
This analog of adenosine interferes with DNA synthesis and may indirectly affect PRIM1 activity by inhibiting DNA polymerases. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
A pyrimidine nucleoside analog that may indirectly inhibit PRIM1 by incorporation into DNA and RNA. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
A guanine analog that can be incorporated into DNA, potentially disrupting the interaction between PRIM1 and its substrates. | ||||||
Clofarabine | 123318-82-1 | sc-278864 sc-278864A | 10 mg 50 mg | $185.00 $781.00 | ||
A purine nucleoside analog that inhibits ribonucleotide reductase, potentially reducing nucleotide pools and affecting PRIM1 activity. | ||||||
2-Chloro-2′-deoxyadenosine | 4291-63-8 | sc-202399 | 10 mg | $144.00 | 1 | |
It is a synthetic purine analog that may disrupt DNA synthesis and consequently the demand for PRIM1 activity. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
An inhibitor of ribonucleotide reductase, it may deplete deoxyribonucleotides and indirectly inhibit PRIM1 function. | ||||||
Pentostatin | 53910-25-1 | sc-204177 sc-204177A | 10 mg 50 mg | $175.00 $702.00 | 5 | |
An adenosine deaminase inhibitor that could disrupt DNA replication, potentially affecting PRIM1's role. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
A dihydrofolate reductase inhibitor that may lead to a decrease in nucleotide synthesis, indirectly affecting PRIM1 activity. | ||||||