Molecular structure of 1-β-D-Arabinofuranosylcytosine, CAS Number: 147-94-4
1-β-D-Arabinofuranosylcytosine (CAS 147-94-4)
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Alternate Names:
Cytosine 1-β-D-arabinofuranoside; Arabinosylcytosine
Application:
1-β-D-Arabinofuranosylcytosine is a cystosine analog and a potent inhibitor of replicative DNA synthesis
CAS Number:
147-94-4
Purity:
≥99%
Molecular Weight:
243.20
Molecular Formula:
C9H13N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-beta-D-Arabinofuranosylcytosine, a cytosine analogue, inhibits DNA polymerases alpha, delta, and epsilon, and RNA polymerases resulting in suppression of DNA synthesis and repair. 1-beta-D-Arabinofuranosylcytosine acts as an antimetabolic agent which is responsible for damaging DNA during the S-phase of the cell cycle. In addition, 1-beta-D-Arabinofuranosylcytosine inhibits nucleotide reductase enzymes that are needed for DNA synthesis to occur. Alternate studies suggest that 1-beta-D-Arabinofuranosylcytosine is clastogenic to both spermatogonial cells and bone marrow. Furthermore, 1-beta-D-Arabinofuranosylcytosine can be used to control the proliferation of glial cells.
1-β-D-Arabinofuranosylcytosine (CAS 147-94-4) References
- Cell cycle specificity of cytogenetic damage induced by 3,4-epoxy-1- butene. | Kligerman, AD., et al. 1999. Mutat Res. 444: 151-8. PMID: 10477349
- Quantitation of synergism of arabinosylcytosine and cladribine against the growth of arabinosylcytosine-resistant human lymphoid cells. | Han, T., et al. 2005. J Cancer Res Clin Oncol. 131: 609-16. PMID: 16044347
- Evaluation of synergism of drugs cis-diamminedichloroplatinum (II) and arabinosylcytosine on the level of chemical interaction with DNA and on the growth of mouse leukemia. | Rauko, P., et al. 1991. Gen Pharmacol. 22: 805-10. PMID: 1761184
- Cytosine arabinoside-induced cytogenotoxicity in bone marrow and spermatogonial cells of mice and its potential transmission through the male germline. | Palo, AK., et al. 2009. Mutat Res. 673: 29-36. PMID: 19095079
- Pharmacologic studies of cyclocytidine and arabinosylcytosine in dogs. | Ho, DH., et al. 1975. Drug Metab Dispos. 3: 309-13. PMID: 240662
- DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia. | Nabel, CS., et al. 2017. Biochemistry. 56: 2166-2169. PMID: 28394581
- Combination strategies to promote sensitivity to cytarabine-induced replication stress in acute myeloid leukemia with and without DNMT3A mutations. | Shabashvili, DE., et al. 2022. Exp Hematol. 110: 20-27. PMID: 35306047
- Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine. | Furth, JJ. and Cohen, SS. 1968. Cancer Res. 28: 2061-7. PMID: 5754840
- Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics. | Papayannopoulou, T., et al. 1984. Science. 224: 617-9. PMID: 6200940
- Correlation of mouse tissue distribution of arabinosylcytosine in vivo with enzymatic activities in vitro. | Ho, DH. 1976. Drug Metab Dispos. 4: 296-300. PMID: 6236
- Toxicity of combinations of arabinosylcytosine and 3-deazauridine toward neoplastic cells in culture. | Mills-Yamamoto, C., et al. 1978. Biochem Pharmacol. 27: 181-6. PMID: 623673
- The disposition of new arabinosylcytosine derivative-- 5'-chloro-5'-deoxy-arabinosylcytosine--in rats. | Novotný, L., et al. 1995. Gen Pharmacol. 26: 1101-5. PMID: 7557257
- Formation of beta-galactosyl compounds of arabinosylcytosine in growing culture of Sporobolomyces singularis. | Suzuki, Y. and Uchida, K. 1994. Biosci Biotechnol Biochem. 58: 639-43. PMID: 7764857
Inhibitor of:
4921523A10Rik, 6030422M02Rik, ARL2, ASPG, Barhl1, Blood Group M antigen, C2orf12, C3orf37_8430410A17Rik, C4ST-1, C6orf167, dCK, DDEF1, DNA pol α, DNA pol β, DNA pol δ cat, DNA pol δ cat, DNA pol δ ss, DNA pol ε, DNA pol ν, DNA pol alpha, dNT-1, DSPG3, DTYMK, EXT2, FRG2B, GATC, Glycophorin C, H2-M10.3, H2-M5, H2AL2, Hbb-bh1, HemT-1, HHV-8 gp64, HISPPD2A, Histone cluster 3 H2ba, HL60 Antigen, HoxA10, HS6ST1, HTLV-1 p24, hunchback, ICSBP, IVD, KIAA0391, KIR3DL1, KRTAP9-1, Laminin β-4, LASS1, LOC100041179, LOC647166, LRIT3, Macrophagee Marker, MOG, MUP15, MUP19, Myeloid lineage, Myeloid Marker, NASP, Nestin, Neuroplastin, NT5DC2, OBFC1, Olfr71, Olfr710, Olfr711, Olr63, p53R2, PCDHGA4, PCDHGA8, PD-ECGF, Pol I/II/III RPB8, Pol III RPC32, POLR3K, PR48, PRIM1, PRIM2A, Psf1, R2, RBPMS, RCBTB1, RCC1, REXO2, RIG-I, RNA Polymerase, RNase Z1, RNGTT, Rnr1, rotavirus vp7, Rpp29, RRP22, S-100A16, SAMHD1, SH3TC2, Slfn5, TFIIH p8, THUMPD2, Tns3, v-Myb, VSTM2L, and WT1.Activator of:
ADO, ASPG, Bcl-3, CBWD, CDD, CTP, Eps8L3, MPO, NET1, plakophilin 3, Psf2, RILP, RmlB, SRGAP2P1, TRB-3, and UPase 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-β-D-Arabinofuranosylcytosine, 1 g | sc-201628 | 1 g | $150.00 | |||
1-β-D-Arabinofuranosylcytosine, 5 g | sc-201628A | 5 g | $263.00 | |||
1-β-D-Arabinofuranosylcytosine, 25 g | sc-201628B | 25 g | $518.00 | |||
1-β-D-Arabinofuranosylcytosine, 100 g | sc-201628C | 100 g | $731.00 | |||
1-β-D-Arabinofuranosylcytosine, 250 g | sc-201628D | 250 g | $1461.00 |