PRDM14 Activators
PRDM14 activators refer to a group of compounds that modulate the function of PR domain-containing protein 14 (PRDM14), a member of the PRDM family of proteins that has roles in the regulation of gene expression, particularly in the maintenance of pluripotency in embryonic stem cells and the establishment of the germ cell lineage. PRDM14 exerts its function through its role as a transcription regulator, influencing the expression of genes associated with stem cell identity and differentiation.
The activation of PRDM14 by chemical activators can occur through various mechanisms. Some activators may directly interact with PRDM14, enhancing its stability or facilitating its interaction with chromatin, thereby promoting its transcriptional activity. Other activators may operate indirectly by modulating signaling pathways that influence PRDM14 activity. For instance, these chemicals might inhibit negative regulators of PRDM14 or upregulate signaling molecules that contribute to its activation. In the field of research, understanding the activation of PRDM14 is pivotal for dissecting the mechanisms that underlie stem cell maintenance and differentiation. By employing PRDM14 activators, researchers can study the effects of increased PRDM14 activity on gene expression profiles and epigenetic states of cells. These activators thus serve as important tools for probing the molecular pathways that PRDM14 regulates and for clarifying its role in cellular processes such as pluripotency and lineage specification.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This is a DNA methyltransferase inhibitor that can prevent DNA methylation, a process that often inhibits PRDM14. By inhibiting DNA methylation, 5-Aza-2'-deoxycytidine can enhance PRDM14 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This is a histone deacetylase inhibitor. Inhibition of histone deacetylation can lead to a more open chromatin structure, which can enhance PRDM14 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is another histone deacetylase inhibitor. By inhibiting histone deacetylation, Vorinostat can potentially enhance PRDM14 expression. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
This is a G9a histone methyltransferase inhibitor. By inhibiting G9a, BIX-01294 can prevent methylation of histone H3 at lysine 9 (H3K9), a modification that typically represses PRDM14. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is another G9a histone methyltransferase inhibitor. By inhibiting G9a, UNC0638 can prevent H3K9 methylation and thus enhance PRDM14 expression. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
This is a histone deacetylase inhibitor. Inhibition of histone deacetylation can lead to a more open chromatin structure, which can enhance PRDM14 expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor. It can prevent DNA methylation, a process that often inhibits PRDM14, thereby enhancing PRDM14 expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
This is a histone deacetylase inhibitor. Inhibition of histone deacetylation can lead to a more open chromatin structure, which can enhance PRDM14 expression. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is a specific inhibitor of the histone methyltransferase SUV39H1. Inhibition of SUV39H1 can prevent methylation of H3K9, a modification that typically represses PRDM14, thus enhancing PRDM14 expression. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E64D is a cathepsin inhibitor. Cathepsins can degrade PRDM14, so by inhibiting these enzymes, E64D can increase PRDM14 concentration. | ||||||