PQLC2 Activators
PQLC2 Activators form a distinct class of chemical compounds or molecules that have attracted attention in the field of molecular biology and cellular research. These activators are specifically designed or identified with the aim of modulating the activity of the PQLC2 gene. PQLC2, or Protein Quality Control Factor C2, is a protein-coding gene found in various organisms, including humans. It plays a role in protein quality control within cells, ensuring that misfolded or damaged proteins are correctly processed and degraded, thereby maintaining cellular homeostasis.
The study of PQLC2 activators is of significant interest because it provides researchers with a means to explore the precise role of the PQLC2 gene in cellular physiology and molecular mechanisms associated with protein quality control. Activation of PQLC2 can offer insights into its involvement in the complex process of recognizing and managing aberrant proteins, which is vital for overall cell function and health. By manipulating the activity of PQLC2 through these activators, scientists aim to gain a deeper understanding of the intricate molecular pathways and cellular functions that rely on the gene product, thereby contributing to the broader knowledge of gene regulation and cellular behavior. Consequently, PQLC2 activators serve as valuable tools for researchers dedicated to unraveling the intricate molecular mechanisms that govern cellular biology and the specific roles played by individual genes in these processes, particularly in the context of protein quality control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
As an mTOR inhibitor, Torin 1 might induce autophagy and lysosomal biogenesis, potentially upregulating PQLC2 as part of the cellular response. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to inhibit lysosomal function, chloroquine might induce a compensatory upregulation of lysosomal proteins including PQLC2. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $29.00 $164.00 $255.00 | 2 | |
This disaccharide can induce autophagy, potentially enhancing the expression of lysosomal transporters like PQLC2 to manage increased autophagic flux. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
As an inhibitor of the vacuolar-type H+-ATPase, it could disrupt lysosomal acidification, possibly leading to upregulation of lysosomal proteins to compensate. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An inducer of autophagy through mTOR inhibition, which might increase the demand for lysosomal transporters, including PQLC2. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Induces metabolic stress by inhibiting glycolysis, potentially leading to upregulation of transporters involved in nutrient salvage pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that induces cellular stress, potentially leading to upregulation of proteins involved in cellular homeostasis, including PQLC2. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Induces ER stress, potentially leading to upregulation of lysosomal proteins as part of the unfolded protein response. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Induces ER stress by inhibiting N-linked glycosylation, which could lead to upregulation of lysosomal components to manage misfolded proteins. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
An essential amino acid that might regulate mTOR signaling and thereby influence the expression of genes related to lysosomal function. | ||||||