PQLC2 Inhibitors
PQLC2 inhibitors are a class of chemical compounds designed to specifically target and block the function of PQLC2, a protein that is part of the solute carrier family involved in lysosomal and cellular transport. PQLC2 is known to mediate the movement of cationic amino acids and other small molecules across lysosomal membranes. This transport activity is critical for maintaining lysosomal function and cellular homeostasis, as lysosomes play a key role in the degradation and recycling of cellular materials. By facilitating the release or uptake of essential molecules within the lysosome, PQLC2 contributes to the regulation of metabolic processes and intracellular nutrient sensing. Inhibitors of PQLC2 function by blocking its transporter activity, which disrupts the normal flow of molecules through lysosomal membranes, thereby affecting lysosomal and cellular function.
Researchers use PQLC2 inhibitors to better understand the protein's role in intracellular transport and how it affects broader metabolic processes. By inhibiting PQLC2, scientists can study how the impairment of lysosomal transport impacts cellular waste processing, nutrient recycling, and the overall regulation of cellular metabolism. These inhibitors are useful tools for exploring the specific mechanisms through which PQLC2 interacts with other components of the lysosomal transport machinery, shedding light on the dynamic interactions within the lysosome that influence cellular health. Additionally, PQLC2 inhibitors allow researchers to investigate the downstream effects of disrupted lysosomal transport on organelle function and how lysosomal activity integrates with other cellular systems. This research provides important insights into the fundamental processes of cellular transport and metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride inhibits epithelial sodium channels, which are involved in the regulation of sodium and potassium levels in cells. Inhibition of these channels can disrupt the ionic balance and membrane potential, which may inhibit the function of PQ-loop repeat-containing protein 2 by altering its assumed role in ionic transport across membranes. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain specifically inhibits the Na+/K+-ATPase pump, which maintains the electrochemical gradient across the cell membrane. By inhibiting this pump, the gradient is disrupted, potentially inhibiting PQ-loop repeat-containing protein 2, which may rely on this gradient for its function. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin is a Na+/K+-ATPase inhibitor similar to ouabain, and it disrupts the ionic gradient across cell membranes. The resulting disruption can inhibit the activity of PQ-loop repeat-containing protein 2 if its function is dependent on the maintenance of this gradient. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid inhibits organic anion transporters and can influence cellular efflux mechanisms. This inhibition can lead to an accumulation of substrates within the cell, potentially inhibiting PQ-loop repeat-containing protein 2 by altering substrate availability that it may transport. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that inhibits the influx of calcium ions. Calcium signaling is crucial for various cellular processes, and by inhibiting these signals, it can inhibit PQ-loop repeat-containing protein 2 if the protein's function is calcium-dependent. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine inhibits voltage-gated sodium channels and potassium channels, affecting the membrane potential and cellular excitability. By altering these electrical properties, it may inhibit PQ-loop repeat-containing protein 2, particularly if it is involved in cellular responses to electrical stimuli. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 specifically inhibits the vacuolar-type H+-ATPase (V-ATPase), which can disrupt the acidification of intracellular compartments. As a result, it can inhibit PQ-loop repeat-containing protein 2 by affecting the protein's function in endosomal or lysosomal acidification. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Concanamycin A is also an inhibitor of V-ATPase, similar to Bafilomycin A1, and disrupts intracellular compartment acidification. The inhibition of this acidification can influence the activity of PQ-loop repeat-containing protein 2 by affecting the pH-dependent processes it may be involved in. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts ionic gradients by facilitating the transport of sodium and hydrogen ions across cellular membranes. This disruption can inhibit PQ-loop repeat-containing protein 2 by perturbing the ionic environment that it operates within. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid is an inhibitor of chloride channels and can disrupt chloride ion homeostasis in cells. By inhibiting these channels, it can inhibit PQ-loop repeat-containing protein 2 by altering chloride ion concentrations that may be essential for the protein's function. | ||||||