PPIH Inhibitors are a set of chemical compounds that can potentially decrease the functional activity of PPIH through specific signaling pathways or biological processes that it is directly involved in. Calcineurin inhibitors like Cyclosporin A and FK506 inhibit the dephosphorylation and nuclear translocation of NFAT transcription factors, which can regulate the expression of PPIH, thus inhibiting its function. Similarly, Okadaic acid and Calyculin A, potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A), can affect the phosphorylation state of various proteins, indirectly inhibiting the functional activity of PPIH.
Kinase inhibitors including Staurosporine, BisindolylmaleimideI, H-89, Genistein, PD98059, SB203580, Rapamycin, and LY294002, each target different kinases involved in diverse signaling pathways. For instance, Staurosporine suppresses protein kinases, thereby altering the phosphorylation state of proteins and indirectly inhibiting the functional activity of PPIH. Bisindolylmaleimide I specifically inhibits protein kinase C (PKC) and H-89 targets protein kinase A (PKA), both of which play key roles in various signaling pathways. Genistein, a potent inhibitor of protein tyrosine kinases, also influences the phosphorylation state of proteins and indirectly inhibits the functional activity of PPIH. PD98059, an inhibitor of MEK within the MAPK/ERK pathway, SB203580, a p38 MAPK inhibitor, Rapamycin, an mTOR inhibitor, and LY294002, a PI3K inhibitor, all potentially inhibit PPIH by affecting the phosphorylation state of proteins involved in their respective pathways.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506, or tacrolimus, is another potent calcineurin inhibitor. Like Cyclosporin A, FK506 inhibits the dephosphorylation and nuclear translocation of NFAT transcription factors, therefore, it can inhibit the functional activity of PPIH. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A (PP1 and PP2A), which regulate multiple signaling pathways. By inhibiting these phosphatases, Okadaic acid can affect the phosphorylation state of various proteins and indirectly inhibit the functional activity of PPIH. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of PP1 and PP2A, similar to Okadaic acid. It can alter the phosphorylation state of proteins involved in signaling pathways that indirectly influence the function of PPIH. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which play crucial roles in various signaling pathways. By inhibiting these kinases, Staurosporine can change the phosphorylation state of proteins and indirectly inhibit the functional activity of PPIH. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC), which is involved in various signaling pathways. By inhibiting PKC, Bisindolylmaleimide I can affect the phosphorylation state of proteins and indirectly inhibit the functional activity of PPIH. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a potent and specific inhibitor of protein kinase A (PKA), which regulates various signaling pathways. By inhibiting PKA, H-89 can affect the phosphorylation state of proteins and indirectly inhibit the functional activity of PPIH. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a potent inhibitor of protein tyrosine kinases, which are involved in various signaling pathways. By inhibiting these kinases, Genistein can affect the phosphorylation state of proteins and indirectly inhibit the functional activity of PPIH. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, a kinase involved in the MAPK/ERK pathway. By inhibiting MEK, PD98059 can affect the phosphorylation state of ERK and indirectly inhibit the functional activity of PPIH. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, another kinase involved in various signaling pathways. By inhibiting p38 MAPK, SB203580 can affect the phosphorylation state of proteins and indirectly inhibit the functional activity of PPIH. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a kinase involved in cell growth and proliferation. By inhibiting mTOR, Rapamycin can influence various signaling pathways and indirectly inhibit the functional activity of PPIH. |